amsacrine and Benign Neoplasms, Brain
amsacrine has been researched along with Benign Neoplasms, Brain in 5 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to fabricate and investigate amsacrine containing polymeric rods for use in interstitial chemotherapy of malignant glioma." | 7.69 | Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model. ( Almqvist, PM; Boëthius, J; Glantz, MJ; Wahlberg, LU, 1996) |
| "The purpose of this study was to fabricate and investigate amsacrine containing polymeric rods for use in interstitial chemotherapy of malignant glioma." | 3.69 | Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model. ( Almqvist, PM; Boëthius, J; Glantz, MJ; Wahlberg, LU, 1996) |
| "Dexrazoxane (ICRF-187) is a catalytic inhibitor of the nuclear enzyme DNA topoisomerase II (topo II)." | 1.30 | Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide. ( Holm, B; Jensen, PB; Sehested, M, 1998) |
| "with either L1210 cells or Ehrlich ascites tumor cells." | 1.29 | ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors. ( Holm, B; Jensen, PB; Sehested, M, 1996) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Asano, T | 1 |
| Zwelling, LA | 2 |
| An, T | 1 |
| McWatters, A | 1 |
| Herzog, CE | 1 |
| Mayes, J | 1 |
| Loughlin, SM | 1 |
| Kleinerman, ES | 1 |
| Holm, B | 2 |
| Jensen, PB | 2 |
| Sehested, M | 2 |
| Wahlberg, LU | 1 |
| Almqvist, PM | 1 |
| Glantz, MJ | 1 |
| Boëthius, J | 1 |
| Estey, E | 1 |
| Silberman, L | 1 |
| Doyle, S | 1 |
| Hittelman, W | 1 |
Other Studies
5 other studies available for amsacrine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.
Topics: Amsacrine; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1996 |
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; B | 1996 |
Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model.
Topics: Amsacrine; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Division; Delayed-Actio | 1996 |
Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neo | 1998 |
Effect of cell proliferation and chromatin conformation on intercalator-induced, protein-associated DNA cleavage in human brain tumor cells and human fibroblasts.
Topics: Amsacrine; Brain Neoplasms; Cell Division; Chromatin; DNA; DNA Topoisomerases, Type II; Fibroblasts; | 1987 |