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amsacrine and Benign Neoplasms, Brain

amsacrine has been researched along with Benign Neoplasms, Brain in 5 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to fabricate and investigate amsacrine containing polymeric rods for use in interstitial chemotherapy of malignant glioma."7.69Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model. ( Almqvist, PM; Boëthius, J; Glantz, MJ; Wahlberg, LU, 1996)
"The purpose of this study was to fabricate and investigate amsacrine containing polymeric rods for use in interstitial chemotherapy of malignant glioma."3.69Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model. ( Almqvist, PM; Boëthius, J; Glantz, MJ; Wahlberg, LU, 1996)
"Dexrazoxane (ICRF-187) is a catalytic inhibitor of the nuclear enzyme DNA topoisomerase II (topo II)."1.30Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide. ( Holm, B; Jensen, PB; Sehested, M, 1998)
"with either L1210 cells or Ehrlich ascites tumor cells."1.29ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors. ( Holm, B; Jensen, PB; Sehested, M, 1996)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asano, T1
Zwelling, LA2
An, T1
McWatters, A1
Herzog, CE1
Mayes, J1
Loughlin, SM1
Kleinerman, ES1
Holm, B2
Jensen, PB2
Sehested, M2
Wahlberg, LU1
Almqvist, PM1
Glantz, MJ1
Boëthius, J1
Estey, E1
Silberman, L1
Doyle, S1
Hittelman, W1

Other Studies

5 other studies available for amsacrine and Benign Neoplasms, Brain

ArticleYear
Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.
    British journal of cancer, 1996, Volume: 73, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1;

1996
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:3

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; B

1996
Polymeric controlled-release amsacrine chemotherapy in an experimental glioma model.
    Acta neurochirurgica, 1996, Volume: 138, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Division; Delayed-Actio

1996
Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:6

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neo

1998
Effect of cell proliferation and chromatin conformation on intercalator-induced, protein-associated DNA cleavage in human brain tumor cells and human fibroblasts.
    Cancer research, 1987, Jan-01, Volume: 47, Issue:1

    Topics: Amsacrine; Brain Neoplasms; Cell Division; Chromatin; DNA; DNA Topoisomerases, Type II; Fibroblasts;

1987