amsacrine has been researched along with Ataxia Telangiectasia in 5 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufmann, WK | 1 |
| Boyer, JC | 1 |
| Estabrooks, LL | 1 |
| Wilson, SJ | 1 |
| Cunningham, JM | 1 |
| Francis, GE | 1 |
| Holland, MJ | 1 |
| Pirollo, KF | 1 |
| Chang, EH | 1 |
| Henner, WD | 1 |
| Blazka, ME | 1 |
| Smith, PJ | 1 |
| Makinson, TA | 1 |
| Davies, SM | 1 |
| Harris, AL | 1 |
| Hickson, ID | 1 |
5 other studies available for amsacrine and Ataxia Telangiectasia
| Article | Year |
|---|---|
Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes.
Topics: Amsacrine; Ataxia Telangiectasia; Camptothecin; Cell Line; DNA; DNA Damage; DNA Replication; Drug Re | 1991 |
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
Topics: Amsacrine; Ataxia Telangiectasia; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytarabi | 1991 |
Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide.
Topics: Aminoacridines; Amsacrine; Ataxia Telangiectasia; Bleomycin; Cell Survival; Cells, Cultured; DNA; Et | 1986 |
Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line.
Topics: Amsacrine; Ataxia Telangiectasia; Cell Line; DNA; DNA Damage; DNA Topoisomerases, Type II; Humans | 1989 |
Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant.
Topics: Amsacrine; Animals; Ataxia Telangiectasia; Blotting, Western; Camptothecin; Cell Line; Cell Survival | 1989 |