amsacrine has been researched along with Adenocarcinoma, Basal Cell in 16 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amsacrine is an aminoacridine that binds to DNA by intercalation." | 5.29 | Induction of small intestinal adenocarcinomas in Wistar rats administered amsacrine. ( Courtney, C; Gough, A; Graziano, M, 1994) |
| " The effect of DACA on the cytokinetics of cultured Lewis lung adenocarcinoma cells was compared with those of two clinical drugs of this class, doxorubicin and amsacrine." | 3.68 | Cytokinetic differences in the action of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin. ( Baguley, BC; Finlay, GJ; Haldane, A; Holdaway, KM, 1993) |
| "The coumermycin antibiotic novobiocin, which interacts with the nuclear enzyme topoisomerase II, produced supra-additive toxicity to WEHI-3B D+ leukemia cells at clinically achievable concentrations, when combined with teniposide (VM-26) or etoposide (VP-16)." | 3.68 | Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26). ( Lorico, A; Rappa, G; Sartorelli, AC, 1992) |
| "Amsacrine is an aminoacridine that binds to DNA by intercalation." | 1.29 | Induction of small intestinal adenocarcinomas in Wistar rats administered amsacrine. ( Courtney, C; Gough, A; Graziano, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perni, RB | 1 |
| Wentland, MP | 1 |
| Huang, JI | 1 |
| Powles, RG | 1 |
| Aldous, S | 1 |
| Klingbeil, KM | 1 |
| Peverly, AD | 1 |
| Robinson, RG | 1 |
| Corbett, TH | 1 |
| Jones, JL | 1 |
| Mattes, KC | 1 |
| Rake, JB | 1 |
| Coughlin, SA | 1 |
| Hilgers, RD | 1 |
| Legha, SS | 1 |
| Johnston, GA | 1 |
| Alberts, DS | 1 |
| Stephens, RL | 1 |
| Tranum, BL | 1 |
| Hannigan, EV | 1 |
| Sternberg, CN | 1 |
| Magill, GB | 2 |
| Sordillo, PP | 2 |
| Cheng, E | 1 |
| Currie, VE | 1 |
| Earhart, RH | 1 |
| Elson, PJ | 1 |
| Rosenthal, SN | 1 |
| Hahn, RG | 1 |
| Slayton, RE | 1 |
| Amrein, PC | 1 |
| Coleman, M | 1 |
| Richards, F | 1 |
| Poulin, RF | 1 |
| Berkowitz, I | 1 |
| Kennedy, BJ | 1 |
| Green, M | 1 |
| Herschkopf, R | 1 |
| Rafla, S | 1 |
| Schneider, RJ | 1 |
| Woodcock, TM | 1 |
| Yagoda, A | 1 |
| Nichols, WC | 1 |
| Eagan, RT | 1 |
| Frytak, S | 1 |
| Ingle, JN | 1 |
| Creagan, ET | 1 |
| Kvols, LK | 1 |
| Ratanatharathorn, V | 1 |
| Drelichman, A | 1 |
| Sexon-Porte, M | 1 |
| Al-Sarraf, M | 1 |
| Gralla, RJ | 1 |
| Kelsen, DP | 1 |
| Brenner, DE | 1 |
| Garbino, C | 1 |
| Kasdorf, H | 1 |
| Villasanta, U | 1 |
| Polcaro, R | 1 |
| Yovarone, J | 1 |
| Aisner, J | 1 |
| Schiffer, CA | 1 |
| Wiernik, PH | 1 |
| Kearsley, JH | 1 |
| Page, JP | 1 |
| Levi, JA | 1 |
| Woods, RL | 1 |
| Tattersall, MH | 1 |
| Fox, RM | 1 |
| Coates, AS | 1 |
| Gough, A | 1 |
| Courtney, C | 1 |
| Graziano, M | 1 |
| Haldane, A | 1 |
| Holdaway, KM | 1 |
| Finlay, GJ | 1 |
| Baguley, BC | 1 |
| Rappa, G | 1 |
| Lorico, A | 1 |
| Sartorelli, AC | 1 |
| Lefevre, D | 1 |
| Riou, JF | 1 |
| Ahomadegbe, JC | 1 |
| Zhou, DY | 1 |
| Benard, J | 1 |
| Riou, G | 1 |
| Long, BH | 1 |
| Musial, ST | 1 |
| Brattain, MG | 1 |
16 other studies available for amsacrine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Screening Assays, Antitumor; Enz | 1998 |
m-AMSA and adenocarcinoma of the endometrium. A Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Blood; Drug Evaluation; Female; Humans; Midd | 1984 |
Phase II evaluation of m-AMSA (4'-(9-acridinylamino)-methanesulfon-m-anisidide) in patients with adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Hum | 1983 |
Phase II study of PALA and AMSA in advanced renal cell carcinoma.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents; A | 1983 |
Phase II study of amsacrine in metastatic renal cell carcinoma: a Cancer and Leukemia Group B study.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Drug Evaluation; Female; Humans | 1983 |
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop | 1980 |
Phase II evaluation of AMSA in patients with metastatic lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1980 |
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m--anisidine (AMSA) in patients with advanced head and neck cancers.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1982 |
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA) in patients with gastric adenocarcinoma.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Anemia; Antineoplastic Agents; Drug Evaluation; Humans; L | 1982 |
A phase II trial of m-AMSA in the treatment of advanced gynecologic malignancies.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Eva | 1982 |
Meta AMSA (m-AMSA) in patients with advanced ovarian carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Fema | 1982 |
Induction of small intestinal adenocarcinomas in Wistar rats administered amsacrine.
Topics: Adenocarcinoma; Amsacrine; Animals; Dose-Response Relationship, Drug; Female; Intestinal Mucosa; Int | 1994 |
Cytokinetic differences in the action of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin.
Topics: Acridines; Adenocarcinoma; Amsacrine; Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Doxorubicin; | 1993 |
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
Topics: Adenocarcinoma; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA; DNA T | 1992 |
Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and acidic glutathione S transferase.
Topics: Adenocarcinoma; Amsacrine; Animals; Biomarkers, Tumor; Breast Neoplasms; DNA Damage; DNA Topoisomera | 1991 |
Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Cells, Cultured; DNA; DNA Repair; Etoposide; Humans; Lung | 1985 |