amsacrine has been researched along with Acute Lymphoid Leukemia in 28 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated." | 7.68 | Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Chun, HG; Cook, P; Feldman, EJ; Marboe, C; Mehta, R; Mittelman, A; Puccio, C, 1991) |
| "The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated." | 3.68 | Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Chun, HG; Cook, P; Feldman, EJ; Marboe, C; Mehta, R; Mittelman, A; Puccio, C, 1991) |
| "In all, 625 patients with acute lymphoblastic leukemia (ALL) entered the Leucémie Aiguë Lymphoblastique de l'Adulte-94 trial from June 1994 to June 1999, and received a 4-week induction therapy followed either by chemotherapy alone or stem cell transplantation (SCT)." | 2.71 | Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia. ( Boiron, JM; Buzyn, A; Delannoy, A; Fegueux, N; Fière, D; Gardin, C; Georges, M; Hacini, M; Huguet, F; Kuentz, M; Lhéritier, V; Micléa, JM; Reman, O; Stamatoullas, A; Thomas, X; Vernant, JP, 2004) |
| "Twenty-nine patients with acute myeloid leukemia (AML) received a salvage therapy of amsacrine plus IDAC and etoposide, while 22 patients with acute lymphoblastic leukemia (ALL) received amsacrine plus IDAC." | 2.71 | Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia. ( Ahn, BM; Baek, JH; Jeon, SB; Kim, DH; Kim, JG; Lee, KB; Moon, JH; Sohn, SK; Sung, WJ, 2005) |
| "5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin has been applied in a treatment protocol for patients with a relapse of acute myeloid or lymphocytic leukemia." | 2.68 | A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893). ( Archimbaud, E; Berneman, Z; Dardenne, M; Dohner, H; Jaksic, B; Jehn, U; Labar, B; Louwagie, EA; Muus, P; Stryckmans, P; Suciu, S; Tjean, M; Wijermans, P; Willemze, R; Zittoun, R, 1997) |
| "Treatment with voriconazole in association with transfusions of leukocytes led to clinical and microbiological cure." | 1.33 | [Disseminated cutaneous and visceral fusariosis in an aplastic patient: an unusual digestive entry]. ( Berthou, C; Eveillard, JR; Ianoto, JC; Karam, A; Le Flohic, AM; Le Roy, JP; Misery, L; Quinio, D, 2005) |
| "The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL." | 1.33 | Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children. ( Escherich, G; Hassenpflug, WA; Horstmann, MA; Janka, G; Kabisch, H; zur Stadt, U, 2005) |
| "The prognosis for DS acute myeloid leukemia (AML) is better than for non-DS AML, but the clinical outcome of DS acute lymphoblastic leukemia (ALL) is equal to that of non-DS ALL." | 1.31 | Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. ( Creutzig, U; de Vries, E; Hählen, K; Huismans, DR; Janka-Schaub, GE; Jansen, G; Kaspers, GJ; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Zwaan, CM, 2002) |
| "The clinical outlook for adults with acute lymphoblastic leukemia (ALL) has improved with the use of intensive chemotherapy." | 1.29 | Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults. ( Welborn, JL, 1994) |
| "Effects of amsacrine in combination with other anticancer agents at ID80 were evaluated by cell growth assay using a human T-cell leukemia cell line (MOLT-3)." | 1.28 | Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture. ( Akutsu, M; Inoue, Y; Kano, Y; Kasahara, T; Miura, Y; Sakamoto, S, 1991) |
| "Thus, the CR rate for relapsed ANLL patients who received the higher doses of both agents was 40% (13 of 33)." | 1.28 | Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. ( Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 13 (46.43) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH | 1 |
| Lin, YW | 1 |
| Zhang, X | 1 |
| Chou, TC | 1 |
| Tsai, TJ | 1 |
| Kapuriya, N | 1 |
| Kakadiya, R | 1 |
| Su, TL | 1 |
| Zohren, F | 1 |
| Czibere, A | 1 |
| Bruns, I | 1 |
| Fenk, R | 1 |
| Schroeder, T | 1 |
| Gräf, T | 1 |
| Haas, R | 1 |
| Kobbe, G | 1 |
| Wernstedt, P | 1 |
| Brune, M | 1 |
| Andersson, PO | 1 |
| Gustavsson, B | 1 |
| Stockelberg, D | 1 |
| Wadenvik, H | 1 |
| Frost, BM | 1 |
| Nygren, P | 1 |
| Gustafsson, G | 1 |
| Forestier, E | 1 |
| Jonsson, OG | 1 |
| Kanerva, J | 1 |
| Nygaard, R | 1 |
| Schmiegelow, K | 1 |
| Larsson, R | 1 |
| Lönnerholm, G | 1 |
| Reman, O | 1 |
| Buzyn, A | 1 |
| Lhéritier, V | 1 |
| Huguet, F | 1 |
| Kuentz, M | 1 |
| Stamatoullas, A | 1 |
| Delannoy, A | 1 |
| Fegueux, N | 1 |
| Micléa, JM | 1 |
| Boiron, JM | 2 |
| Vernant, JP | 1 |
| Gardin, C | 1 |
| Hacini, M | 1 |
| Georges, M | 1 |
| Fière, D | 3 |
| Thomas, X | 3 |
| Karam, A | 1 |
| Eveillard, JR | 1 |
| Ianoto, JC | 1 |
| Quinio, D | 1 |
| Le Flohic, AM | 1 |
| Le Roy, JP | 1 |
| Misery, L | 1 |
| Berthou, C | 1 |
| Sung, WJ | 1 |
| Kim, DH | 1 |
| Sohn, SK | 1 |
| Kim, JG | 1 |
| Baek, JH | 1 |
| Jeon, SB | 1 |
| Moon, JH | 1 |
| Ahn, BM | 1 |
| Lee, KB | 1 |
| Horstmann, MA | 1 |
| Hassenpflug, WA | 1 |
| zur Stadt, U | 1 |
| Escherich, G | 1 |
| Janka, G | 1 |
| Kabisch, H | 1 |
| Archimbaud, E | 4 |
| Charrin, C | 1 |
| Magaud, JP | 1 |
| Cortes, J | 1 |
| O'Brien, SM | 1 |
| Pierce, S | 1 |
| Keating, MJ | 1 |
| Freireich, EJ | 1 |
| Kantarjian, HM | 1 |
| Willemze, R | 4 |
| Muus, P | 2 |
| Zijlmans, JM | 1 |
| den Ottolander, GJ | 1 |
| Kluin-Nelemans, JC | 1 |
| Falkenburg, JH | 1 |
| Starrenburg, CW | 1 |
| van der Burgh, JF | 1 |
| Fibbe, WE | 1 |
| Welborn, JL | 1 |
| Jehn, U | 2 |
| Heinemann, V | 1 |
| Dekker, AW | 1 |
| van't Veer, MB | 1 |
| Sizoo, W | 1 |
| Haak, HL | 1 |
| van der Lelie, J | 1 |
| Ossenkoppele, G | 1 |
| Huijgens, PC | 1 |
| Schouten, HC | 1 |
| Sonneveld, P | 1 |
| Verdonck, LF | 1 |
| van Putten, WL | 1 |
| Löwenberg, B | 1 |
| Suciu, S | 1 |
| Stryckmans, P | 1 |
| Louwagie, EA | 1 |
| Berneman, Z | 1 |
| Tjean, M | 1 |
| Wijermans, P | 1 |
| Dohner, H | 1 |
| Labar, B | 1 |
| Jaksic, B | 1 |
| Dardenne, M | 1 |
| Zittoun, R | 1 |
| Zwaan, CM | 1 |
| Kaspers, GJ | 1 |
| Pieters, R | 1 |
| Hählen, K | 1 |
| Janka-Schaub, GE | 1 |
| van Zantwijk, CH | 1 |
| Huismans, DR | 1 |
| de Vries, E | 1 |
| Rots, MG | 1 |
| Peters, GJ | 1 |
| Jansen, G | 1 |
| Creutzig, U | 1 |
| Veerman, AJ | 1 |
| Bernasconi, C | 1 |
| Lazzarino, M | 1 |
| Morra, E | 1 |
| Alessandrino, EP | 1 |
| Pagnucco, G | 1 |
| Resegotti, L | 1 |
| Locatelli, F | 1 |
| Ficarra, F | 1 |
| Bacigalupo, A | 1 |
| Carella, AM | 1 |
| Arlin, ZA | 3 |
| Feldman, EJ | 1 |
| Mittelman, A | 1 |
| Ahmed, T | 1 |
| Puccio, C | 1 |
| Chun, HG | 1 |
| Cook, P | 1 |
| Baskind, P | 1 |
| Marboe, C | 1 |
| Mehta, R | 1 |
| Kano, Y | 1 |
| Sakamoto, S | 1 |
| Kasahara, T | 1 |
| Akutsu, M | 1 |
| Inoue, Y | 1 |
| Miura, Y | 1 |
| Danks, MK | 1 |
| Schmidt, CA | 1 |
| Deneka, DA | 1 |
| Beck, WT | 1 |
| Reiffers, J | 1 |
| Marit, G | 1 |
| Rice, A | 1 |
| Bernard, P | 1 |
| Vezon, G | 1 |
| Weers-Pothoff, G | 1 |
| Novakova, IR | 1 |
| Donnelly, JP | 1 |
| Muytjens, HL | 1 |
| Mirro, J | 1 |
| Kalwinsky, DK | 1 |
| Grier, HE | 1 |
| Santana, VM | 1 |
| Mason, C | 1 |
| Murphy, SB | 1 |
| Dahl, GV | 1 |
1 review available for amsacrine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Mitoxantrone and amsacrine: two important agents for the treatment of acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL).
Topics: Amsacrine; Daunorubicin; Drug Evaluation; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Precursor | 1989 |
9 trials available for amsacrine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Fludarabine, amsacrine, high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is effective in patients with relapsed or high-risk acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Fr | 2009 |
Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2004 |
Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Diar | 2005 |
High-dose Ara-C for remission induction and consolidation of previously untreated adults with ALL or lymphoblastic lymphoma.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 1995 |
[Phase II clinical trial of domestic amsacrine in patients with acute leukemias. Cooperative Group for Treating Acute Leukemias with Domestic m-AMSA].
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relation | 1993 |
Phase-II study of treatment of refractory acute leukemia with intermediate-dose cytosine arabinoside and amsacrine.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug | 1993 |
Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group.
Topics: Adolescent; Adult; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; An | 1997 |
A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893).
Topics: Adolescent; Adult; Aged; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1997 |
Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 1992 |
18 other studies available for amsacrine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.
Topics: Amsacrine; Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; M | 2009 |
Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia.
Topics: Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; | 2002 |
Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyto | 2003 |
[Disseminated cutaneous and visceral fusariosis in an aplastic patient: an unusual digestive entry].
Topics: Adult; Amsacrine; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Die | 2005 |
Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Comb | 2005 |
CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Aneuploidy; Antibiotics, Antineoplastic; Antigens, CD; Antigens, | 1995 |
The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocol | 1995 |
Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group.
Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Agents; Azacitidine; Decitabine; F | 1993 |
Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Aspartate-Ammonia Ligase; Clinical | 1994 |
Influence of increased body mass index on drug toxicity in patients with acute promyelocytic leukemia.
Topics: Adult; Aged; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 1998 |
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Topics: Amsacrine; Anthracyclines; Antineoplastic Agents; Busulfan; Cell Survival; Child; Child, Preschool; | 2002 |
Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.
Topics: Amsacrine; Cardiac Output, Low; Cytarabine; Drug Therapy, Combination; Humans; Leukemia; Leukemia, M | 1991 |
Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Dose-Response Relationship | 1991 |
Increased ATP requirement for activity of and complex formation by DNA topoisomerase II from human leukemic CCRF-CEM cells selected for resistance to teniposide.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Amsacrine; Cell Line; Cell Nucleus; DNA Topoisome | 1989 |
The role of peripheral blood stem cells as rescue after myeloablative therapy.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Combined Modality Ther | 1989 |
Bacteraemia caused by Stomatococcus mucilaginosus in a granulocytopenic patient with acute lymphocytic leukaemia.
Topics: Adult; Agranulocytosis; Amsacrine; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Proto | 1989 |
A special role for amsacrine in the treatment of acute leukemia.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Humans; Leukemia, Myeloid, Acute; Precurs | 1989 |
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; C | 1989 |