amsacrine has been researched along with Abnormalities, Drug-Induced in 3 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Quantifying the embryotoxic effects of these drugs revealed that the no observed adverse effect level (NOAEL) for m-AMSA is 10 nM, the embryotoxic concentration range is 50-500 nM, and complete lethality is observed at 1 microM." | 1.28 | Embryotoxicity of the intercalating agents m-AMSA and o-AMSA and the epipodophyllotoxin VP-16 in postimplantation rat embryos in vitro. ( Mirkes, PE; Zwelling, LA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henck, JW | 1 |
| Brown, SL | 1 |
| Anderson, JA | 2 |
| Mirkes, PE | 1 |
| Zwelling, LA | 1 |
| Petrere, JA | 1 |
| Sakowski, R | 1 |
| Fitzgerald, JE | 1 |
| de la Iglesia, FA | 1 |
3 other studies available for amsacrine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Developmental toxicity of CI-921, an anilinoacridine antitumor agent.
Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Antineoplastic Agents; Embryo Implantation; Female; | 1992 |
Embryotoxicity of the intercalating agents m-AMSA and o-AMSA and the epipodophyllotoxin VP-16 in postimplantation rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Antineoplastic Agents; DNA Damage; DNA Topoisomeras | 1990 |
Teratology study in rats with amsacrine, an antineoplastic agent.
Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Embryonic and Fetal Development; Female; Fetal Deat | 1986 |