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amsacrine and Abnormalities, Drug-Induced

amsacrine has been researched along with Abnormalities, Drug-Induced in 3 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
" Quantifying the embryotoxic effects of these drugs revealed that the no observed adverse effect level (NOAEL) for m-AMSA is 10 nM, the embryotoxic concentration range is 50-500 nM, and complete lethality is observed at 1 microM."1.28Embryotoxicity of the intercalating agents m-AMSA and o-AMSA and the epipodophyllotoxin VP-16 in postimplantation rat embryos in vitro. ( Mirkes, PE; Zwelling, LA, 1990)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Henck, JW1
Brown, SL1
Anderson, JA2
Mirkes, PE1
Zwelling, LA1
Petrere, JA1
Sakowski, R1
Fitzgerald, JE1
de la Iglesia, FA1

Other Studies

3 other studies available for amsacrine and Abnormalities, Drug-Induced

ArticleYear
Developmental toxicity of CI-921, an anilinoacridine antitumor agent.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Antineoplastic Agents; Embryo Implantation; Female;

1992
Embryotoxicity of the intercalating agents m-AMSA and o-AMSA and the epipodophyllotoxin VP-16 in postimplantation rat embryos in vitro.
    Teratology, 1990, Volume: 41, Issue:6

    Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Antineoplastic Agents; DNA Damage; DNA Topoisomeras

1990
Teratology study in rats with amsacrine, an antineoplastic agent.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Amsacrine; Animals; Embryonic and Fetal Development; Female; Fetal Deat

1986