Page last updated: 2024-10-22

amsacrine and Abnormalities, Autosome

amsacrine has been researched along with Abnormalities, Autosome in 22 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"The present study was designed to determine and compare the clastogenicity of m-AMSA and camptothecin (CAMP) in vivo in mouse bone marrow and peripheral blood lymphocytes (PBLs), and in vitro in mouse lymphoma L5178Y cells."3.68Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. ( Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM, 1990)
"We propose two mechanisms for aneuploidy by amsacrine (or related topo II poisons), either of which can be readily detected using FISH."1.29Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. ( Baguley, BC; Ferguson, LR; Holdaway, KM; Whiteside, G, 1996)
"The frequencies of chromosomal aberrations and sister chromatid exchanges (SCE) were studied in human peripheral lymphocytes after exposure of whole blood cultures to the antitumour agent m-AMSA."1.28The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA. ( Andersson, HC; Kihlman, BA, 1989)
"The antitumor drug amsacrine causes chromosomal aberrations both in cultured cells (L1210 murine leukemia and HeLa cells) and in vivo (L1210 leukemia)."1.27Relationship between the induction of chromosome damage and cytotoxicity for amsacrine and congeners. ( Baguley, BC; Ferguson, LR, 1984)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's10 (45.45)18.2507
2000's3 (13.64)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Perel, Y1
Auvrignon, A1
Leblanc, T1
Michel, G1
Vannier, JP1
Dalle, JH1
Gandemer, V1
Schmitt, C1
Mèchinaud, F1
Lamagnere, JP1
Piguet, Ch1
Couillaud, G1
Pautard, B1
Baruchel, A1
Leverger, G1
Parry, JM1
Fowler, P1
Quick, E1
Parry, EM1
Ferguson, LR5
Baguley, BC3
Wilson, WR1
Harris, NM1
Allen, JW2
Poorman-Allen, P1
Collins, BW1
Sontag, MR1
Thomas, X1
Archimbaud, E1
Charrin, C1
Magaud, JP1
Fiere, D1
Cortés, F3
Piñero, J3
Palitti, F2
Whiteside, G1
Holdaway, KM1
Mosesso, P1
Darroudi, F1
van den Berg, M1
Vermeulen, S1
Natarajan, AT1
López-Baena, M1
Mateos, S1
Sumner, AT2
Nørgaard, JM1
Olesen, LH1
Olesen, G1
Meyer, K1
Kristensen, JS1
Bendix, K1
Pedersen, B1
Kjeldsen, E1
Hokland, P1
Backer, LC1
Harrington-Brock, K2
Campbell, JA1
DeMarini, DM2
Doerr, CL3
Howard, DR1
Kligerman, AD1
Moore, MM3
Andersson, HC1
Kihlman, BA1
Pommier, Y2
Kerrigan, D1
Covey, JM1
Kao-Shan, CS2
Whang-Peng, J2
Meyer, MK1
Brock, KH1
Hozier, J1
Zwelling, LA1
Bradley, MO1
van Zijl, P2
Nesnow, S1

Trials

1 trial available for amsacrine and Abnormalities, Autosome

ArticleYear
Maintenance therapy in childhood acute myeloid leukemia.
    Annals of hematology, 2004, Volume: 83 Suppl 1

    Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow

2004

Other Studies

21 other studies available for amsacrine and Abnormalities, Autosome

ArticleYear
Investigations into the biological relevance of in vitro clastogenic and aneugenic activity.
    Cytogenetic and genome research, 2004, Volume: 104, Issue:1-4

    Topics: Alkylating Agents; Amsacrine; Aneuploidy; Cells, Cultured; Chromosome Aberrations; Chromosomes, Huma

2004
Relationship between the induction of chromosome damage and cytotoxicity for amsacrine and congeners.
    Cancer treatment reports, 1984, Volume: 68, Issue:4

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Chromosome Aber

1984
Comparison of the mutagenic and clastogenic activity of amsacrine and other DNA-intercalating drugs in cultured V79 Chinese hamster cells.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Aminoacridines; Amsacrine; Animals; Carcinogens; Cell Division; Cell Line; Cell Survival; Chromosome

1984
Synaptonemal complex aberrations in the pseudoautosomal region of X, Y chromosomes in irradiated hamsters.
    Mutagenesis, 1994, Volume: 9, Issue:3

    Topics: Amsacrine; Animals; Bleomycin; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Damage; Male; Mic

1994
CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia.
    Leukemia, 1995, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Aged; Amsacrine; Aneuploidy; Antibiotics, Antineoplastic; Antigens, CD; Antigens,

1995
Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.
    Mutation research, 1993, Volume: 288, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases,

1993
Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:5

    Topics: Amsacrine; Animals; Camptothecin; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Dam

1994
Application of fluorescence in situ hybridisation to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine.
    Environmental and molecular mutagenesis, 1996, Volume: 27, Issue:4

    Topics: Amsacrine; Analysis of Variance; Aneuploidy; Animals; Antineoplastic Agents; Cell Cycle; Cell Divisi

1996
Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques.
    Mutagenesis, 1998, Volume: 13, Issue:1

    Topics: Amsacrine; Azure Stains; Chromosome Aberrations; Chromosome Banding; Etoposide; Humans; Male; Staini

1998
Enhanced sensitivity to topoisomerase inhibitors in synchronous CHO cells pre-treated with 5-azacytidine.
    Mutation research, 1998, Oct-12, Volume: 421, Issue:1

    Topics: Amsacrine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, P

1998
Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II.
    Chromosoma, 1998, Volume: 107, Issue:6-7

    Topics: Amsacrine; Animals; CHO Cells; Chromatids; Chromosome Aberrations; Chromosome Segregation; Cricetina

1998
FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemia.
    European journal of haematology, 2001, Volume: 67, Issue:4

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antigens, Neoplas

2001
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
    Journal of cell science, 1992, Volume: 103 ( Pt 1)

    Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerase

1992
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
    Mutagenesis, 1990, Volume: 5, Issue:6

    Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome

1990
Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells.
    Mutation research, 1989, Volume: 222, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoacridines; Amsacrine; Animals; Bleomycin; Chromosome Aberrati

1989
The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA.
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Amsacrine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes; Culture Media; Cytarabi

1989
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
    Cancer research, 1988, Feb-01, Volume: 48, Issue:3

    Topics: Amsacrine; Animals; Camptothecin; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Drug

1988
Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase.
    Mutagenesis, 1987, Volume: 2, Issue:5

    Topics: Amsacrine; Animals; Cell Survival; Chromosome Aberrations; DNA Topoisomerases, Type II; Hypoxanthine

1987
Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Aminoacridines; Amsacrine; Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetin

1985
Comparison of the mutagenicity of amsacrine with that of a new clinical analogue, CI-921.
    Mutation research, 1988, Volume: 204, Issue:2

    Topics: Amsacrine; Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Chromosome Aberrations

1988
Morphological transformation and chromosome damage by amsacrine in C3H/10T1/2 clone 8 cells.
    Mutation research, 1986, Volume: 170, Issue:3

    Topics: Aminoacridines; Amsacrine; Animals; Cell Line; Cell Nucleus; Cell Survival; Cell Transformation, Neo

1986