amrinone has been researched along with Myocardial Ischemia in 10 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 5.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Amrinone produced an increase in CO comparable to that of OPC-18790; however, the increase in peak LVdP/dt was smaller while the increase in HR and decrease in mBP were larger than those seen with OPC-18790." | 1.29 | Effects of OPC-18790, a new positive inotropic agent, on energetics in the ischaemic canine heart: a 31P-MRS study. ( Fujiki, H; Ishikawa, M; Itoh, S; Koga, K; Mori, T; Tominaga, M; Yabuuchi, Y, 1995) |
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 1.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Amrinone did not produce significant increases in preload recruitable stroke work area at 0." | 1.29 | The effects of amrinone versus dobutamine on myocardial mechanics and energetics after hypothermic global ischemia. ( Berman, K; Fahey, AL; Isom, OW; Ko, W; Krieger, KH; Lang, D; Zelano, JA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishikawa, M | 2 |
| Mori, T | 2 |
| Itoh, S | 2 |
| Fujiki, H | 1 |
| Koga, K | 2 |
| Tominaga, M | 2 |
| Yabuuchi, Y | 2 |
| Massardo, T | 1 |
| Maiers, E | 1 |
| Zamorano, J | 1 |
| Berr, ML | 1 |
| Ayala, F | 1 |
| Ramírez, A | 1 |
| Arriagada, M | 1 |
| González, P | 1 |
| Alliende, I | 1 |
| Rump, AF | 3 |
| Acar, D | 1 |
| Klaus, W | 3 |
| Watanabe, N | 1 |
| Maekawa, K | 1 |
| Nakase, A | 1 |
| Ookawa, Y | 1 |
| Tanaka, A | 1 |
| Satoh, T | 1 |
| Umami, T | 1 |
| Blazincic, B | 1 |
| Tse, J | 1 |
| Cimini, C | 1 |
| Kedem, J | 1 |
| Rodriquez, E | 1 |
| Gonzalez, M | 1 |
| Weiss, HR | 1 |
| Rösen, R | 1 |
| Sigmund, B | 1 |
| Fuchs, J | 1 |
| Dhein, S | 1 |
| Sidi, A | 1 |
| Pool, JM | 1 |
| Rush, W | 1 |
| Ko, W | 1 |
| Zelano, JA | 1 |
| Fahey, AL | 1 |
| Berman, K | 1 |
| Lang, D | 1 |
| Isom, OW | 1 |
| Krieger, KH | 1 |
10 other studies available for amrinone and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of OPC-18790, a new positive inotropic agent, on energetics in the ischaemic canine heart: a 31P-MRS study.
Topics: Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Dogs; Dose-Response Rel | 1995 |
Differential effects of OPC-18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea-pig isolated ischaemic heart.
Topics: Adenosine Triphosphate; Amrinone; Animals; Cardiac Pacing, Artificial; Cardiotonic Agents; Coronary | 1995 |
[Tomographic myocardial perfusion (SPECT) using 99mTc sestamibi-dipyridamole and 2-d-echocardiography with amrinone pre and post myocardial revascularization in 2 cases].
Topics: Amrinone; Coronary Angiography; Coronary Disease; Dipyridamole; Echocardiography; Follow-Up Studies; | 1994 |
A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Electric Stimulation; Heart; Heart Rate | 1994 |
[Hemodynamic effects of Amrinone in patients following open heart surgery].
Topics: Adolescent; Adult; Aged; Amrinone; Cardiac Surgical Procedures; Female; Hemodynamics; Humans; Male; | 1994 |
Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Fluorescence; Hemodynamics; Histocytoch | 1993 |
Role of ischemia-reperfusion on myocardial cyclic AMP and cyclic AMP phosphodiesterase: effects of amrinone on regional myocardial force and shortening.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Animals; Blood Pressure; Coronary Vessels; Cyclic AMP | 1993 |
Beneficial effect of amrinone on the size of acute regional ischemia in isolated rabbit hearts.
Topics: Amrinone; Animals; Blood Pressure; Coronary Circulation; Fluorescence; Histocytochemistry; In Vitro | 1993 |
Early administration of amrinone does not impair regional metabolism of O2 or lactate and, by improving myocardial performance, preserves myocardial blood flow in the ischemic canine heart.
Topics: Amrinone; Animals; Coronary Circulation; Dogs; Female; Heart; Lactates; Male; Myocardial Ischemia; O | 1993 |
The effects of amrinone versus dobutamine on myocardial mechanics and energetics after hypothermic global ischemia.
Topics: Amrinone; Animals; Coronary Vessels; Dobutamine; Dogs; Hypothermia, Induced; In Vitro Techniques; My | 1993 |