amrinone has been researched along with Muscle Relaxation in 17 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to examine and compare pulmonary vascular smooth muscle relaxation by clinically used agents as related to cGMP mediation (sodium nitroprusside, nitroglycerin) and cAMP mediation (isoproterenol, prostaglandin E1 (PGE1), and amrinone) in isolated rat pulmonary arterial rings." | 3.69 | Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms. ( Banerjee, A; Fullerton, DA; Hahn, AR; Harken, AH, 1994) |
| " We found a shift in the dose-response curve of only phosphodiesterase 5 inhibitors." | 1.32 | The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips. ( Bagcivan, I; Gokce, G; Kilicarslan, H; Sarac, B; Sarioglu, Y; Yildirim, S, 2003) |
| "Diltiazem was the most potent airway relaxant, and amrinone was less potent in these experiments." | 1.31 | Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle. ( Kiyota, T; Matsuda, F; Sadohara, T; Sugahara, K; Sugita, M; Terasaki, H, 2000) |
| " Among them, 3,4-dipropyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-i]-purin-5-one (1c), which was the most selective and potent PDE IV inhibitor, did not cause emesis in Suncus murinus at a dosage range of 10-100 mg/kg (po), while an imidazole analogue of 1c (4c) and known PDE IV inhibitors such as rolipram and denbufylline caused emesis even at 10 or 30 mg/kg." | 1.30 | Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. ( Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S, 1997) |
| "Milrinone was more potent as a vasorelaxant in coronary arteries relative to cerebral or renal arteries regardless of the mode of contraction; amrinone was coronary selective with K+ contraction only." | 1.28 | Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries. ( Alousi, AA; Evans, DB; Grant, AM; Harris, AL; Silver, PJ, 1989) |
| "Treatment with amrinone potentiated the relaxant responses of mesenteric arteries to adenosine but did not alter the response to isoprenaline." | 1.27 | Responses of isolated dog arteries to amrinone. ( Miyazaki, M; Nakajima, M; Nishimura, K; Toda, N, 1984) |
| "When amrinone was examined for its inhibition of histamine contractions under modified Ca2+ availability, the EC25 and EC75 of amrinone were 76 and 8 times smaller, respectively, under conditions of intracellular rather than normal Ca2+ availability." | 1.26 | Relaxant effects of amrinone upon pulmonary smooth muscle. ( Buck, DC; Mielens, ZE, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sawanishi, H | 1 |
| Suzuki, H | 1 |
| Yamamoto, S | 1 |
| Waki, Y | 1 |
| Kasugai, S | 1 |
| Ohya, K | 1 |
| Suzuki, N | 1 |
| Miyamoto, K | 1 |
| Takagi, K | 1 |
| Aydin, C | 1 |
| Bagcivan, I | 2 |
| Yildirim, S | 3 |
| Koyuncu, A | 1 |
| Topcu, O | 1 |
| Soylu, S | 1 |
| Ozer, H | 1 |
| Kilicarslan, H | 1 |
| Gokce, G | 1 |
| Sarac, B | 1 |
| Sarioglu, Y | 2 |
| Toda, N | 1 |
| Nakajima, M | 1 |
| Nishimura, K | 1 |
| Miyazaki, M | 1 |
| Osella, R | 2 |
| Piacenza, G | 2 |
| Borgoglio, R | 2 |
| Mielens, ZE | 1 |
| Buck, DC | 1 |
| Kesim, Y | 1 |
| Celik, S | 1 |
| Banoglu, N | 1 |
| Fullerton, DA | 1 |
| Hahn, AR | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Ono, S | 1 |
| Ueda, S | 1 |
| Sakuma, T | 1 |
| Noda, M | 1 |
| Tabata, T | 1 |
| Hoshikawa, Y | 1 |
| Ashino, Y | 1 |
| Tanita, T | 1 |
| Koike, K | 1 |
| Fujimura, S | 1 |
| Kurokawa, Y | 1 |
| Kojima, K | 1 |
| Kanayama, H | 1 |
| Kagawa, S | 1 |
| Minami, K | 1 |
| Nakaya, Y | 1 |
| Usta, C | 1 |
| Sadan, G | 1 |
| Matsuda, F | 1 |
| Sugahara, K | 1 |
| Sugita, M | 1 |
| Sadohara, T | 1 |
| Kiyota, T | 1 |
| Terasaki, H | 1 |
| Utkan, T | 1 |
| Yildirim, MK | 1 |
| Satoh, H | 1 |
| Endoh, M | 1 |
| Harris, AL | 1 |
| Grant, AM | 1 |
| Silver, PJ | 1 |
| Evans, DB | 1 |
| Alousi, AA | 1 |
| Dorigo, P | 1 |
| Ceroni, G | 1 |
| Giacometti, A | 1 |
| Valentini, E | 1 |
| Gaion, RM | 1 |
| Maragno, I | 1 |
17 other studies available for amrinone and Muscle Relaxation
| Article | Year |
|---|---|
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiester | 1997 |
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs.
Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazine | 2009 |
The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips.
Topics: Amrinone; Animals; Body Weight; Calcium; Creatinine; Dose-Response Relationship, Drug; Electric Stim | 2003 |
Responses of isolated dog arteries to amrinone.
Topics: Adenosine; Aminopyridines; Amrinone; Animals; Arteries; Calcium; Cardiotonic Agents; Dinoprost; Dogs | 1984 |
Amrinone relaxing effect on the isolated guinea pig trachea and its interaction with aminophylline.
Topics: Aminophylline; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Dose-Response Relationship, Dr | 1983 |
Relaxant effects of amrinone upon pulmonary smooth muscle.
Topics: Airway Resistance; Aminophylline; Aminopyridines; Amrinone; Animals; Barium; Calcium; Carbachol; Dru | 1982 |
The inhibitory effects of amrinone on isolated rat uterus.
Topics: Aminophylline; Amrinone; Animals; Calcium Chloride; Female; Imidazoles; Muscle Relaxation; Phosphodi | 1994 |
Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms.
Topics: Alprostadil; Amrinone; Analysis of Variance; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relation | 1994 |
[Effect of amurinone on human pulmonary artery in vitro].
Topics: Adult; Aged; Amrinone; Cyclic AMP; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Re | 1994 |
[Muscle-relaxant effect of amrinone on guinea-pig tracheal smooth muscle and its interaction with aminophylline].
Topics: Aminophylline; Amrinone; Animals; Binding, Competitive; Drug Synergism; Guinea Pigs; Male; Muscle Re | 1983 |
Activation of the Ca2+-activated K+ channel via protein kinase A-dependent phosphorylation in human prostatic smooth muscle cells.
Topics: Adenylyl Cyclases; Amrinone; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent P | 1998 |
Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats.
Topics: Amrinone; Animals; Carbachol; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dose-Response Rel | 2000 |
Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle.
Topics: Acetylcholine; Adrenergic beta-Agonists; Aminophylline; Amrinone; Animals; Bronchodilator Agents; Ca | 2000 |
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro.
Topics: Amrinone; Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Imidazoles; Male; Muscle C | 2001 |
Effects of a new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-[imidazo (1,2-a) pyridin-6-yl]-3-pyridine carbonitrile hydrochloride monohydrate (E-1020) on contractile force and cyclic AMP metabolism in canine ventricular muscle.
Topics: Amrinone; Animals; Bupranolol; Carbachol; Cardiotonic Agents; Cyclic AMP; Dogs; Female; Heart; Heart | 1990 |
Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amrinone; Animals; Cerebral Arte | 1989 |
The response of isolated guinea-pig aorta to amrinone.
Topics: Adenosine; Adenosine Deaminase; Amrinone; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Te | 1988 |