amrinone has been researched along with Muscle Contraction in 24 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force." | 1.35 | Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. ( Albet-Torres, N; Barman, T; Bloemink, MJ; Candau, R; Frölander, K; Geeves, MA; Golker, K; Herrmann, C; Lionne, C; Månsson, A; Piperio, C; Schmitz, S; Veigel, C, 2009) |
| "Amrinone was added cumulatively every 5 min to muscle specimens in order to obtain organ bath concentrations between 20 and 400 micromol L(-1)." | 1.33 | Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine. ( Fiege, M; Gerbershagen, MU; Kolodzie, K; Schulte am Esch, J; Wappler, F; Weisshorn, R, 2005) |
| "Amrinone was found to depress Ca-Mg dependent ATPase activity of myofibrillar preparations of the tibialis anterior (up to 16." | 1.29 | Effects of amrinone on shortening velocity and force development in skinned skeletal muscle fibres. ( Bottinelli, R; Cappelli, V; Morner, SE; Reggiani, C, 1993) |
| "Amrinone (0." | 1.27 | Inotropic effect of amrinone in rabbit papillary muscle: reversal of the myocardial depressant effect of halothane. ( Komai, H; Rusy, BF, 1984) |
| "Treatment with amrinone potentiated the relaxant responses of mesenteric arteries to adenosine but did not alter the response to isoprenaline." | 1.27 | Responses of isolated dog arteries to amrinone. ( Miyazaki, M; Nakajima, M; Nishimura, K; Toda, N, 1984) |
| "Amrinone was administered as an intravenous bolus of 2 mg/kg followed by a continuous infusion of 25 micrograms." | 1.27 | Effect of amrinone on diaphragm blood flow. ( Arnold, JS; Bundy, RJ; DiMarco, AF; Hussein, F; Supinski, GS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (58.33) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Månsson, A | 6 |
| Rassier, DE | 1 |
| Albet-Torres, N | 1 |
| Bloemink, MJ | 1 |
| Barman, T | 1 |
| Candau, R | 1 |
| Frölander, K | 1 |
| Geeves, MA | 1 |
| Golker, K | 1 |
| Herrmann, C | 1 |
| Lionne, C | 1 |
| Piperio, C | 1 |
| Schmitz, S | 1 |
| Veigel, C | 1 |
| Fiege, M | 1 |
| Wappler, F | 1 |
| Weisshorn, R | 1 |
| Gerbershagen, MU | 1 |
| Kolodzie, K | 1 |
| Schulte am Esch, J | 1 |
| Ishida, Y | 1 |
| Ohizumi, Y | 1 |
| Shibata, S | 1 |
| Komai, H | 1 |
| Rusy, BF | 1 |
| Toda, N | 1 |
| Nakajima, M | 1 |
| Nishimura, K | 1 |
| Miyazaki, M | 1 |
| Edman, KA | 3 |
| Binah, O | 1 |
| Legato, MJ | 1 |
| Danilo, P | 1 |
| Rosen, MR | 1 |
| Osella, R | 1 |
| Piacenza, G | 1 |
| Borgoglio, R | 1 |
| Meisheri, KD | 1 |
| Hwang, O | 1 |
| van Breemen, C | 1 |
| Fujii, Y | 1 |
| Toyooka, H | 1 |
| Amaha, K | 1 |
| Bottinelli, R | 1 |
| Cappelli, V | 1 |
| Morner, SE | 2 |
| Reggiani, C | 1 |
| Sasaki, J | 1 |
| Kunimoto, F | 1 |
| Isa, Y | 1 |
| Ohki, S | 1 |
| Tsukagoshi, H | 1 |
| Yoshikawa, D | 1 |
| Ishikawa, S | 1 |
| Koyama, H | 1 |
| Goto, F | 1 |
| Usta, C | 1 |
| Sadan, G | 1 |
| Utkan, T | 1 |
| Yildirim, MK | 1 |
| Yildirim, S | 1 |
| Sarioglu, Y | 1 |
| Mörner, J | 1 |
| Stone, TW | 1 |
| Paton, DM | 1 |
| Bundy, RJ | 1 |
| Arnold, JS | 1 |
| DiMarco, AF | 1 |
| Hussein, F | 1 |
| Supinski, GS | 1 |
| Dorigo, P | 2 |
| Gaion, RM | 2 |
| Giacometti, A | 2 |
| Ceroni, G | 2 |
| Maragno, I | 2 |
| Marcomini, A | 1 |
| Hagen, A | 1 |
| Krause, W | 1 |
| Göres, E | 1 |
24 other studies available for amrinone and Muscle Contraction
| Article | Year |
|---|---|
Insights into Muscle Contraction Derived from the Effects of Small-Molecular Actomyosin-Modulating Compounds.
Topics: Actins; Actomyosin; Adenosine Triphosphate; Amrinone; Isometric Contraction; Models, Biological; Mus | 2022 |
Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin.
Topics: Actomyosin; Adenosine Diphosphate; Amrinone; Animals; Calcium Channel Blockers; In Vitro Techniques; | 2009 |
Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Anesthesia, General; Animals; Calcium; Cyclic AMP; Cy | 2005 |
Excitatory and inhibitory actions of amrinone on the guinea-pig isolated ileum and vas deferens.
Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Drug Interactions; Electric Stimulation; Guin | 1982 |
Inotropic effect of amrinone in rabbit papillary muscle: reversal of the myocardial depressant effect of halothane.
Topics: Aminopyridines; Amrinone; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Halothane; In Vitro | 1984 |
Responses of isolated dog arteries to amrinone.
Topics: Adenosine; Aminopyridines; Amrinone; Animals; Arteries; Calcium; Cardiotonic Agents; Dinoprost; Dogs | 1984 |
Effects of amrinone on twitch, tetanus and force-velocity relationship in frog skeletal muscle.
Topics: Aminopyridines; Amrinone; Animals; Energy Metabolism; Isometric Contraction; Muscle Contraction; Mus | 1984 |
Developmental changes in the cardiac effects of amrinone in the dog.
Topics: Aging; Aminopyridines; Amrinone; Animals; Animals, Newborn; Dogs; Female; Heart Conduction System; M | 1983 |
Amrinone relaxing effect on the isolated guinea pig trachea and its interaction with aminophylline.
Topics: Aminophylline; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Dose-Response Relationship, Dr | 1983 |
Evidence for two separated Ca2+ pathways in smooth muscle plasmalemma.
Topics: Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; Cell Membrane; Dose-Response Relatio | 1981 |
Amrinone improves contractility of fatigued diaphragm in dogs.
Topics: Amrinone; Animals; Diaphragm; Dogs; Electric Stimulation; Electrophysiology; Fluid Therapy; Infusion | 1995 |
Effects of amrinone on shortening velocity and force development in skinned skeletal muscle fibres.
Topics: Amrinone; Animals; Ca(2+) Mg(2+)-ATPase; Male; Muscle Contraction; Muscles; Myofibrils; Myosins; Rat | 1993 |
[Effects of amrinone on the Ca(2+)-related functions of skinned skeletal muscle fibers of guinea pigs].
Topics: Amrinone; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Guinea Pigs; | 1999 |
Comparison of the hemodynamic effects of amrinone in patients who required low-to-moderate-dose and high-dose catecholamines after cardiac valve replacement.
Topics: Adult; Aged; Amrinone; Analysis of Variance; Cardiotonic Agents; Catheterization, Swan-Ganz; Dobutam | 1999 |
Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats.
Topics: Amrinone; Animals; Carbachol; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dose-Response Rel | 2000 |
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro.
Topics: Amrinone; Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Imidazoles; Male; Muscle C | 2001 |
Effects of amrinone on the electromechanical coupling in frog skeletal muscle fibres.
Topics: Action Potentials; Amrinone; Animals; Biomechanical Phenomena; Differential Threshold; Electrophysio | 1990 |
Effects of amrinone on twitch, tetanus and shortening kinetics in mammalian skeletal muscle.
Topics: Amrinone; Animals; Kinetics; Mice; Muscle Contraction | 1989 |
Actions of amrinone and milrinone on the guinea-pig ileum.
Topics: Amrinone; Animals; Evoked Potentials; Female; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Mil | 1988 |
Effect of amrinone on diaphragm blood flow.
Topics: Amrinone; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Diaphragm; Dogs; Electric St | 1988 |
The role of calcium in amrinone action on intestinal smooth muscle.
Topics: Acetylcholine; Amrinone; Animals; Calcium; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestin | 1987 |
Amrinone action on guinea-pig isolated stomach fundus.
Topics: Adenosine; Adenosine Deaminase; Amrinone; Animals; Calcium; Dipyridamole; Female; Guinea Pigs; In Vi | 1987 |
[Modification of smooth muscle contractility by Cordemcura].
Topics: Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Female; Guinea Pigs; Histamine; In Vitro Tech | 1986 |
Effects of amrinone on the contractile behaviour of frog striated muscle fibres.
Topics: Aminopyridines; Amrinone; Animals; Caffeine; Calcium; Computers; Electric Stimulation; In Vitro Tech | 1985 |