amrinone has been researched along with Hypertension, Pulmonary in 17 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hemodynamic benefits and pulmonary vascular selectivity of amrinone, dobutamine and amrinone + dobutamine were assessed in a canine model of vasoconstrictive pulmonary hypertension." | 7.69 | Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs. ( Dagher, E; Dumont, L, 1994) |
| "Platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) have been implicated in myointimal proliferative arteriopathy, a lesion seen in monocrotaline-induced pulmonary hypertension (MIPH)." | 7.69 | Growth factor expression and effects of amrinone in monocrotaline-induced pulmonary hypertension in rats. ( Banner, W; Burch, GH; Hammond, EH; Jensen, LR; Pappas, J; Shaddy, RE, 1996) |
| "We report two cases in which amrinone was used effectively, in addition to the conventional sympathomimetic drug, for the emergence from cardiopulmonary bypass following complicated valvular heart surgery in patients who had severe pulmonary hypertension and biventricular failure." | 7.68 | Amrinone therapy for severe pulmonary hypertension and biventricular failure after complicated valvular heart surgery. ( Asokumar, B; Cheng, DC; Nakagawa, T, 1993) |
| "Intravenous infusion of group B Streptococcus (GBS) into neonatal animals produces pulmonary hypertension, ventilation/perfusion (VA/Q) mismatch, and an increase in serum levels of thromboxane B2 (TxB2) and tumor necrosis factor (TNF) alpha." | 7.68 | Effect of amrinone during group B Streptococcus-induced pulmonary hypertension in piglets. ( Berger, JI; Clarke, WR; Gibson, RL; Henderson, WR; Redding, GJ; Standaert, TA; Truog, WE, 1993) |
| "The aim of this study was to investigate the haemodynamic effects of amrinone in patients with pulmonary hypertension and impaired right ventricular function." | 7.67 | The haemodynamic effects of amrinone in patients with mitral stenosis and pulmonary hypertension. ( Arnold, B; Hess, W; Veit, S, 1986) |
| "The effects of 3 types of vasoactive agents, hydralazine, nifedipine and amrinone, were evaluated in 7 patients with primary pulmonary hypertension (PPH)." | 7.66 | Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension. ( Ganz, R; Levy, PS; Rich, S, 1983) |
| "Amrinone was more effective in reducing pulmonary hypertension than conventional therapy with high-dose diuretics, digitalis, and captopril (86% v 63%)." | 6.38 | The role of amrinone in potential heart transplant patients with pulmonary hypertension. ( Bolling, SF; Deeb, GM, 1989) |
| "A 55-year-old man developed acute respiratory failure, pulmonary hypertension and left heart failure due to acute myocardial infarction." | 5.30 | Concurrent administration of amrinone with nitric oxide most improves PaO2/FiO2 in acute respiratory and cardiac failure. ( Fujimori, M; Hayashi, M; Yamada, T; Yukioka, H, 1999) |
| "The hemodynamic benefits and pulmonary vascular selectivity of amrinone, dobutamine and amrinone + dobutamine were assessed in a canine model of vasoconstrictive pulmonary hypertension." | 3.69 | Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs. ( Dagher, E; Dumont, L, 1994) |
| "Platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) have been implicated in myointimal proliferative arteriopathy, a lesion seen in monocrotaline-induced pulmonary hypertension (MIPH)." | 3.69 | Growth factor expression and effects of amrinone in monocrotaline-induced pulmonary hypertension in rats. ( Banner, W; Burch, GH; Hammond, EH; Jensen, LR; Pappas, J; Shaddy, RE, 1996) |
| "We report two cases in which amrinone was used effectively, in addition to the conventional sympathomimetic drug, for the emergence from cardiopulmonary bypass following complicated valvular heart surgery in patients who had severe pulmonary hypertension and biventricular failure." | 3.68 | Amrinone therapy for severe pulmonary hypertension and biventricular failure after complicated valvular heart surgery. ( Asokumar, B; Cheng, DC; Nakagawa, T, 1993) |
| "Intravenous infusion of group B Streptococcus (GBS) into neonatal animals produces pulmonary hypertension, ventilation/perfusion (VA/Q) mismatch, and an increase in serum levels of thromboxane B2 (TxB2) and tumor necrosis factor (TNF) alpha." | 3.68 | Effect of amrinone during group B Streptococcus-induced pulmonary hypertension in piglets. ( Berger, JI; Clarke, WR; Gibson, RL; Henderson, WR; Redding, GJ; Standaert, TA; Truog, WE, 1993) |
| "The aim of this study was to investigate the haemodynamic effects of amrinone in patients with pulmonary hypertension and impaired right ventricular function." | 3.67 | The haemodynamic effects of amrinone in patients with mitral stenosis and pulmonary hypertension. ( Arnold, B; Hess, W; Veit, S, 1986) |
| "The effects of 3 types of vasoactive agents, hydralazine, nifedipine and amrinone, were evaluated in 7 patients with primary pulmonary hypertension (PPH)." | 3.66 | Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension. ( Ganz, R; Levy, PS; Rich, S, 1983) |
| "Amrinone was more effective in reducing pulmonary hypertension than conventional therapy with high-dose diuretics, digitalis, and captopril (86% v 63%)." | 2.38 | The role of amrinone in potential heart transplant patients with pulmonary hypertension. ( Bolling, SF; Deeb, GM, 1989) |
| " Vasodilator therapy generally fails to reduce pulmonary vascular resistance selectively during long-term administration and frequently leads to systemic hypotension, exacerbation of the pulmonary hypertensive state, worsening of right ventricular failure, and systemic arterial desaturation." | 2.37 | Vasodilator therapy for primary pulmonary hypertension. Limitations and hazards. ( Packer, M, 1985) |
| "A 55-year-old man developed acute respiratory failure, pulmonary hypertension and left heart failure due to acute myocardial infarction." | 1.30 | Concurrent administration of amrinone with nitric oxide most improves PaO2/FiO2 in acute respiratory and cardiac failure. ( Fujimori, M; Hayashi, M; Yamada, T; Yukioka, H, 1999) |
| "Amrinone is a bipyridine derivative with inotropic and vasodilator effects that have not been systematically evaluated in the pediatric patient with increased pulmonary blood flow." | 1.29 | Selective pulmonary and systemic vasodilator effects of amrinone in children: new therapeutic implications. ( Gelband, H; Mas, MS; Robinson, BW, 1993) |
| "Pulmonary hypertension is associated with an increased perioperative mortality for orthotopic heart transplantation." | 1.28 | Amrinone versus conventional therapy in pulmonary hypertensive patients awaiting cardiac transplantation. ( Bolling, SF; Deeb, GM; Guynn, TP; Nicklas, JM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rich, S | 1 |
| Ganz, R | 1 |
| Levy, PS | 1 |
| Dumont, L | 1 |
| Dagher, E | 1 |
| Cheng, DC | 1 |
| Asokumar, B | 1 |
| Nakagawa, T | 1 |
| Berger, JI | 1 |
| Gibson, RL | 1 |
| Clarke, WR | 1 |
| Standaert, TA | 1 |
| Redding, GJ | 1 |
| Henderson, WR | 1 |
| Truog, WE | 1 |
| Robinson, BW | 1 |
| Gelband, H | 1 |
| Mas, MS | 1 |
| Burch, GH | 1 |
| Jensen, LR | 1 |
| Pappas, J | 1 |
| Hammond, EH | 1 |
| Banner, W | 1 |
| Shaddy, RE | 1 |
| Jenkins, IR | 1 |
| Dolman, J | 1 |
| O'Connor, JP | 1 |
| Ansley, DM | 1 |
| Yukioka, H | 1 |
| Hayashi, M | 1 |
| Yamada, T | 1 |
| Fujimori, M | 1 |
| Deeb, GM | 3 |
| Bolling, SF | 3 |
| Hess, W | 2 |
| Faitg, R | 1 |
| Coulaud, JM | 1 |
| Rezgui, N | 1 |
| Brulot, N | 1 |
| Clavier, H | 1 |
| Besse, B | 1 |
| Labrousse, J | 1 |
| Lissac, J | 1 |
| Guynn, TP | 1 |
| Nicklas, JM | 1 |
| Packer, M | 1 |
| Niu, XL | 1 |
| Xie, ZZ | 1 |
| Crowley, DC | 1 |
| Badellino, MM | 1 |
| Bove, EL | 1 |
| Arnold, B | 1 |
| Veit, S | 1 |
3 reviews available for amrinone and Hypertension, Pulmonary
| Article | Year |
|---|---|
The role of amrinone in potential heart transplant patients with pulmonary hypertension.
Topics: Amrinone; Heart Transplantation; Humans; Hypertension, Pulmonary; Pulmonary Circulation; Vascular Re | 1989 |
Effects of amrinone on the right side of the heart.
Topics: Amrinone; Cardiac Output, Low; Humans; Hypertension, Pulmonary; Ventricular Function, Right | 1989 |
Vasodilator therapy for primary pulmonary hypertension. Limitations and hazards.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Blood Pressure; Ca | 1985 |
1 trial available for amrinone and Hypertension, Pulmonary
| Article | Year |
|---|---|
Amrinone versus dobutamine in cardiac surgical patients with severe pulmonary hypertension after cardiopulmonary bypass: a prospective, randomized double-blinded trial.
Topics: Amrinone; Cardiopulmonary Bypass; Cardiotonic Agents; Dobutamine; Double-Blind Method; Female; Heart | 1997 |
13 other studies available for amrinone and Hypertension, Pulmonary
| Article | Year |
|---|---|
Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension.
Topics: Adult; Aminopyridines; Amrinone; Cardiac Catheterization; Cardiac Output; Female; Humans; Hydralazin | 1983 |
Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs.
Topics: Amrinone; Animals; Dinoprost; Disease Models, Animal; Dobutamine; Dogs; Drug Therapy, Combination; H | 1994 |
Amrinone therapy for severe pulmonary hypertension and biventricular failure after complicated valvular heart surgery.
Topics: Adult; Amrinone; Aortic Valve; Cardiopulmonary Bypass; Drug Therapy, Combination; Female; Heart Fail | 1993 |
Effect of amrinone during group B Streptococcus-induced pulmonary hypertension in piglets.
Topics: Amrinone; Animals; Animals, Newborn; Blood Pressure; Dose-Response Relationship, Drug; Hypertension, | 1993 |
Selective pulmonary and systemic vasodilator effects of amrinone in children: new therapeutic implications.
Topics: Amrinone; Blood Pressure; Child; Child, Preschool; Drug Evaluation; Female; Heart Septal Defects, Ve | 1993 |
Growth factor expression and effects of amrinone in monocrotaline-induced pulmonary hypertension in rats.
Topics: Amrinone; Animals; Body Weight; Bronchi; Cardiotonic Agents; Fibroblast Growth Factor 2; Hypertensio | 1996 |
Concurrent administration of amrinone with nitric oxide most improves PaO2/FiO2 in acute respiratory and cardiac failure.
Topics: Acute Disease; Amrinone; Cardiotonic Agents; Drug Therapy, Combination; Heart Failure; Hemodynamics; | 1999 |
[Hemodynamic effects of amrinone and comparison with dobutamine in patients with chronic respiratory insufficiency with pulmonary hypertension].
Topics: Aged; Amrinone; Dobutamine; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, Ob | 1989 |
Amrinone versus conventional therapy in pulmonary hypertensive patients awaiting cardiac transplantation.
Topics: Adult; Amrinone; Angiotensin-Converting Enzyme Inhibitors; Digitalis Glycosides; Diuretics; Female; | 1989 |
[Hemodynamic effect of domestic amrinone in patients with congestive heart failure and pulmonary hypertension].
Topics: Adolescent; Adult; Aged; Amrinone; Female; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmon | 1988 |
[Effects of amrinone on pulmonary hemodynamics and pulmonary gas exchange in highland piglets].
Topics: Altitude; Amrinone; Animals; Hypertension, Pulmonary; Pulmonary Circulation; Pulmonary Gas Exchange; | 1988 |
Prolonged amrinone therapy prior to orthotopic cardiac transplantation in patients with pulmonary hypertension.
Topics: Adolescent; Adult; Amrinone; Child; Drug Evaluation; Female; Heart Diseases; Heart Failure; Heart Tr | 1988 |
The haemodynamic effects of amrinone in patients with mitral stenosis and pulmonary hypertension.
Topics: Adult; Amrinone; Female; Heart Rate; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Middle Age | 1986 |