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amrinone and Endotoxin Shock

amrinone has been researched along with Endotoxin Shock in 15 studies

Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.

Research Excerpts

ExcerptRelevanceReference
"This study explored the hemodynamic effects of amrinone, a phosphodiesterase inhibitor, in association with intravenous fluids, in the treatment of endotoxin shock."7.67Amrinone administration in endotoxin shock. ( Cantraine, F; Contempré, B; de Boelpaepe, C; Domb, M; Motte, S; Van der Linden, P; Vincent, JL, 1988)
"The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)."5.32[Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003)
"This study explored the hemodynamic effects of amrinone, a phosphodiesterase inhibitor, in association with intravenous fluids, in the treatment of endotoxin shock."3.67Amrinone administration in endotoxin shock. ( Cantraine, F; Contempré, B; de Boelpaepe, C; Domb, M; Motte, S; Van der Linden, P; Vincent, JL, 1988)
"Septic shock is a common clinical problem in the intensive care setting."2.38The pharmacotherapy of septic shock. ( Boyd, JL; Chernow, B; Stanford, GG, 1989)
"The endotoxin shock was induced by intravenously injecting LPS (400 micro g/kg)."1.32[Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits]. ( Fan, XM; Tang, HX, 2003)
"Effects of amrinone (AMR), a phosphodiesterase inhibitor, alone and in combination with dobutamine (DOB), on hemodynamics and O2 delivery were studied during porcine endotoxemia."1.29Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia. ( Dodam, JR; Gengo, PJ; Hellyer, PW; Jones, JL, 1995)
"Amrinone was more effective than ouabain at all left atrial filling pressures tested."1.27Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats. ( Burns, AH; Burns, LA; Shepherd, RE; Summer, WR, 1988)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19906 (40.00)18.7374
1990's8 (53.33)18.2507
2000's1 (6.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tang, HX1
Fan, XM1
Werner, HA1
Herbertson, MJ1
Walley, KR1
Jones, JL1
Gengo, PJ1
Dodam, JR1
Hellyer, PW1
Ryding, J1
Heslet, L1
Hartvig, T1
Jønsson, V1
Ishiki, J1
Carpati, CM1
Astiz, ME1
Rackow, EC1
Hernández, G1
Gigoux, J1
Bugedo, G1
Castillo, L1
Bruhn, A1
Tomicic, V1
Dagnino, J1
González, F1
Giroir, BP1
Beutler, B1
Burns, AH1
Summer, WR1
Burns, LA1
Shepherd, RE1
Boyd, JL1
Stanford, GG1
Chernow, B1
Vincent, JL2
Domb, M2
Van der Linden, P1
Motte, S1
de Boelpaepe, C2
Contempré, B1
Cantraine, F1
Kosugi, I1
Tajimi, K1
Gonda, T1
Fukatsu, O1
Ueda, S1
Hoffmann, P1
Schockenhoff, B1

Reviews

3 reviews available for amrinone and Endotoxin Shock

ArticleYear
[Perioperative management of renal circulation].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46 Suppl

    Topics: Amrinone; Anesthesia; Animals; Glycoproteins; Hemodynamics; Humans; Intraoperative Period; Kidney Tr

1997
Mechanisms and management of myocardial dysfunction in septic shock.
    Critical care medicine, 1999, Volume: 27, Issue:2

    Topics: Amrinone; Animals; Cardiotonic Agents; Epinephrine; Heart; Rats; Shock, Septic; Tumor Necrosis Facto

1999
The pharmacotherapy of septic shock.
    Critical care clinics, 1989, Volume: 5, Issue:1

    Topics: Adrenergic Agonists; Amrinone; Glucagon; Humans; Naloxone; Shock, Septic

1989

Trials

1 trial available for amrinone and Endotoxin Shock

ArticleYear
[Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients].
    Revista medica de Chile, 1999, Volume: 127, Issue:6

    Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Amrinone; Cardiotonic Agents; Dobutamine; Female; Hemodyn

1999

Other Studies

11 other studies available for amrinone and Endotoxin Shock

ArticleYear
[Effect of dexamethasone, aminoguanidin, amrinone on oxygen utilization in endotoxin shock rabbits].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:4

    Topics: Amrinone; Animals; Anti-Inflammatory Agents; Dexamethasone; Enzyme Inhibitors; Female; Guanidines; M

2003
Amrinone increases ventricular contractility and diastolic compliance in endotoxemia.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:2

    Topics: Amrinone; Animals; Atrial Function, Right; Blood Pressure; Cardiac Catheterization; Cardiac Output;

1995
Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia.
    Shock (Augusta, Ga.), 1995, Volume: 3, Issue:3

    Topics: Amrinone; Animals; Disease Models, Animal; Dobutamine; Down-Regulation; Drug Therapy, Combination; H

1995
Reversal of 'refractory septic shock' by infusion of amrinone and angiotensin II in an anthracycline-treated patient.
    Chest, 1995, Volume: 107, Issue:1

    Topics: Amrinone; Angiotensin II; Doxorubicin; Escherichia coli Infections; Female; Humans; Infusions, Intra

1995
[Dobutamine and amrinone in septic shock patients].
    Revista medica de Chile, 1999, Volume: 127, Issue:12

    Topics: Amrinone; Cardiotonic Agents; Dobutamine; Humans; Shock, Septic

1999
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
    Circulatory shock, 1992, Volume: 36, Issue:3

    Topics: Amrinone; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatography; Dexamethasone; Di

1992
Inotropic interactions of dichloroacetate with amrinone and ouabain in isolated hearts from endotoxin-shocked rats.
    Journal of cardiovascular pharmacology, 1988, Volume: 11, Issue:4

    Topics: Acetates; Adenosine Triphosphate; Amrinone; Animals; Cardiac Output; Dichloroacetic Acid; Drug Inter

1988
Amrinone administration in endotoxin shock.
    Circulatory shock, 1988, Volume: 25, Issue:2

    Topics: Amrinone; Animals; Cardiac Output; Combined Modality Therapy; Dogs; Endotoxins; Escherichia coli; Fl

1988
Non-adrenergic inotropic support in septic shock.
    Progress in clinical and biological research, 1987, Volume: 236B

    Topics: Amrinone; Animals; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Contraction; Shock, Septic

1987
[Effect of amrinone on hemodynamics, oxygen consumption and plasma catecholamine levels in endotoxin injected dogs].
    Masui. The Japanese journal of anesthesiology, 1985, Volume: 34, Issue:9

    Topics: Aminopyridines; Amrinone; Animals; Catecholamines; Coronary Circulation; Dogs; Oxygen Consumption; S

1985
[Amrinone in catecholamine refractory heart failure in septic shock].
    Der Anaesthesist, 1985, Volume: 34, Issue:12

    Topics: Adult; Aged; Aminopyridines; Amrinone; Cardiotonic Agents; Catecholamines; Dose-Response Relationshi

1985