amrinone has been researched along with Endotoxemia in 5 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the amrinone + LPS group MAP decreased within the first 30 min of amrinone infusion and decreased further during endotoxemia." | 7.70 | Influence of amrinone on tissue oxygenation of jejunal mucosa during endotoxemia. ( Gebhard, MM; Martin, E; Schmidt, H; Schmidt, W; Tinelli, M; Walther, A, 2000) |
| "The objective of this study was to determine the effects of a continuous infusion of the phosphodiesterase (PDE) inhibitor amrinone on mucosal villus blood flow in a normotensive model of endotoxemia." | 7.70 | Influence of amrinone on intestinal villus blood flow during endotoxemia. ( Gebhard, MM; Martin, E; Schmidt, H; Schmidt, W; Secchi, A; Tinelli, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Németh, ZH | 2 |
| Haskó, G | 2 |
| Szabó, C | 2 |
| Vizi, ES | 2 |
| Salzman, AL | 1 |
| Takeuchi, K | 1 |
| del Nido, PJ | 1 |
| Ibrahim, AE | 1 |
| Cao-Danh, H | 1 |
| Friehs, I | 1 |
| Glynn, P | 1 |
| Poutias, D | 1 |
| Cowan, DB | 1 |
| McGowan, FX | 1 |
| Schmidt, W | 2 |
| Tinelli, M | 2 |
| Walther, A | 1 |
| Gebhard, MM | 2 |
| Martin, E | 2 |
| Schmidt, H | 2 |
| Secchi, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety, Tolerability & Effects of Rolipram on Inflammatory Activity in the Central Nervous System in Multiple Sclerosis. A Phase II, Open Label Crossover Trial Using MRI as an Outcome Measure[NCT00011375] | Phase 2 | 52 participants | Interventional | 2001-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for amrinone and Endotoxemia
| Article | Year |
|---|---|
Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice.
Topics: Amrinone; Animals; Cyclic AMP; Cyclic GMP; Cytokines; Endotoxemia; Interleukin-10; Interleukin-6; Li | 1997 |
Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4 | 1998 |
Vesnarinone and amrinone reduce the systemic inflammatory response syndrome.
Topics: Adjuvants, Immunologic; Amrinone; Animals; Drug Evaluation, Preclinical; Endotoxemia; Endotoxins; He | 1999 |
Influence of amrinone on tissue oxygenation of jejunal mucosa during endotoxemia.
Topics: Amrinone; Animals; Endotoxemia; Hemodynamics; Intestinal Mucosa; Jejunum; Lipopolysaccharides; Male; | 2000 |
Influence of amrinone on intestinal villus blood flow during endotoxemia.
Topics: Amrinone; Analysis of Variance; Animals; Endotoxemia; Hemodynamics; Intestinal Mucosa; Male; Microci | 2000 |