amrinone has been researched along with Disease Models, Animal in 13 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hemodynamic benefits and pulmonary vascular selectivity of amrinone, dobutamine and amrinone + dobutamine were assessed in a canine model of vasoconstrictive pulmonary hypertension." | 7.69 | Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs. ( Dagher, E; Dumont, L, 1994) |
| "Amrinone is a noncatecholamine inotropic agent used clinically in the management of heart failure." | 5.29 | Amrinone improves survival in hemorrhagic shock. ( Cinat, M; Daughters, K; Waxman, K, 1994) |
| "The present study compared the effects of amrinone, dobutamine, dibutyryl cAMP, digoxin, and isoproterenol on mechanical performance, the high energy phosphate metabolites, and the [Ca2+]i transients in normal and cardiomyopathic hamster hearts with severe heart failure." | 3.69 | Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts. ( Buser, PT; Jasmin, G; Parmley, WW; Wikman-Coffelt, J; Wu, SY, 1995) |
| "The hemodynamic benefits and pulmonary vascular selectivity of amrinone, dobutamine and amrinone + dobutamine were assessed in a canine model of vasoconstrictive pulmonary hypertension." | 3.69 | Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs. ( Dagher, E; Dumont, L, 1994) |
| "Effects of amrinone (AMR), a phosphodiesterase inhibitor, alone and in combination with dobutamine (DOB), on hemodynamics and O2 delivery were studied during porcine endotoxemia." | 1.29 | Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia. ( Dodam, JR; Gengo, PJ; Hellyer, PW; Jones, JL, 1995) |
| "Amrinone is a noncatecholamine inotropic agent used clinically in the management of heart failure." | 1.29 | Amrinone improves survival in hemorrhagic shock. ( Cinat, M; Daughters, K; Waxman, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Endoh, M | 1 |
| Wang, Y | 1 |
| Yuan, J | 1 |
| Qian, Z | 1 |
| Zhang, X | 1 |
| Chen, Y | 1 |
| Hou, X | 1 |
| Zou, J | 1 |
| Ko, Y | 1 |
| Morita, K | 1 |
| Nagahori, R | 1 |
| Kinouchi, K | 1 |
| Shinohara, G | 1 |
| Kagawa, H | 1 |
| Hashimoto, K | 1 |
| Tadano, N | 1 |
| Morimoto, S | 1 |
| Yoshimura, A | 1 |
| Miura, M | 1 |
| Yoshioka, K | 1 |
| Sakato, M | 1 |
| Ohtsuki, I | 1 |
| Miwa, Y | 1 |
| Takahashi-Yanaga, F | 1 |
| Sasaguri, T | 1 |
| Kucuk, C | 1 |
| Akcan, A | 1 |
| Akyýldýz, H | 1 |
| Akgun, H | 1 |
| Muhtaroglu, S | 1 |
| Sozuer, E | 1 |
| Jones, JL | 1 |
| Gengo, PJ | 1 |
| Dodam, JR | 1 |
| Hellyer, PW | 1 |
| Buser, PT | 1 |
| Wu, SY | 1 |
| Parmley, WW | 1 |
| Jasmin, G | 1 |
| Wikman-Coffelt, J | 1 |
| Daughters, K | 1 |
| Cinat, M | 1 |
| Waxman, K | 1 |
| Dumont, L | 1 |
| Dagher, E | 1 |
| Allen, EM | 1 |
| Rowin, M | 1 |
| Pappas, JB | 1 |
| Vernon, DD | 1 |
| Dean, JM | 1 |
| Giroir, BP | 1 |
| Beutler, B | 1 |
| Domb, M | 1 |
| De Boelpaepe, C | 1 |
| Vincent, JL | 1 |
13 other studies available for amrinone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Amrinone, forerunner of novel cardiotonic agents, caused paradigm shift of heart failure pharmacotherapy.
Topics: Amrinone; Animals; Calcium Signaling; Cardiotonic Agents; Chronic Disease; Disease Models, Animal; D | 2013 |
β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amrinone; Animals; Arrhythmias, Ca | 2015 |
Myocardial cyclic AMP augmentation with high-dose PDEIII inhibitor in terminal warm blood cardioplegia.
Topics: Amrinone; Animals; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Cardiotonic Agents; Coronary Circul | 2009 |
SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure.
Topics: Amrinone; Animals; Calcium; Cardiotonic Agents; Dihydropyridines; Disease Models, Animal; Dogs; Hear | 2005 |
Effects of amrinone in an experimental model of hepatic ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine Transaminase; Amrinone; Animals; Aspartate Aminotransferases; Biopsy | 2009 |
Amrinone combined with dobutamine improves hemodynamics and oxygen delivery without down-regulation of cardiac beta-adrenergic receptor density in porcine endotoxemia.
Topics: Amrinone; Animals; Disease Models, Animal; Dobutamine; Down-Regulation; Drug Therapy, Combination; H | 1995 |
Distinct modulation of myocardial performance, energy metabolism, and [Ca2+]i transients by positive inotropic drugs in normal and severely failing hamster hearts.
Topics: Amrinone; Animals; Blood Pressure; Bucladesine; Calcium; Cardiomyopathies; Cardiotonic Agents; Crice | 1995 |
Amrinone improves survival in hemorrhagic shock.
Topics: Amrinone; Animals; Blood Pressure; Disease Models, Animal; Drug Evaluation, Preclinical; Infusions, | 1994 |
Effects of amrinone and dobutamine on PGF2 alpha-induced pulmonary hypertension in dogs.
Topics: Amrinone; Animals; Dinoprost; Disease Models, Animal; Dobutamine; Dogs; Drug Therapy, Combination; H | 1994 |
Hemodynamic effects of N-acetylamrinone in a porcine model of group B streptococcal sepsis.
Topics: Amrinone; Animals; Disease Models, Animal; Hemodynamics; Lung; Streptococcal Infections; Streptococc | 1996 |
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Topics: Amrinone; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatography; Dexamethasone; Di | 1992 |
Non-adrenergic inotropic support in septic shock.
Topics: Amrinone; Animals; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Contraction; Shock, Septic | 1987 |