amrinone has been researched along with Cardiomegaly in 3 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When congestive heart failure supervenes, the prognosis is poor." | 2.37 | Central and peripheral components of cardiac failure. ( Factor, S; Le Jemtel, TH; Mancini, DM; Sonnenblick, EH, 1986) |
| "These findings suggest that in chronic cardiac hypertrophy, contractile responses to phosphodiesterase inhibitors may be preserved despite marked reductions in inotropic responses to beta-adrenoceptor agonists." | 1.33 | Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. ( Norton, G; Osadchii, O; Woodiwiss, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osadchii, O | 1 |
| Norton, G | 1 |
| Woodiwiss, A | 1 |
| Mancini, DM | 1 |
| Le Jemtel, TH | 1 |
| Factor, S | 1 |
| Sonnenblick, EH | 1 |
| Bradley, AB | 1 |
| Baim, DS | 1 |
2 reviews available for amrinone and Cardiomegaly
| Article | Year |
|---|---|
Central and peripheral components of cardiac failure.
Topics: Aminopyridines; Amrinone; Animals; Captopril; Cardiac Output; Cardiomegaly; Cardiotonic Agents; Cate | 1986 |
Measurement of coronary blood flow in man: methods and implications for clinical practice.
Topics: Amrinone; Angina Pectoris; Animals; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary V | 1985 |
1 other study available for amrinone and Cardiomegaly
| Article | Year |
|---|---|
Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Animals; Blood Pressure; Cardiomegaly; Cardiotonic | 2005 |