amrinone has been researched along with Cardiac Output, Low in 37 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intravenous amrinone has been shown clinically to improve hemodynamic status remarkably in the patient experiencing a low cardiac output syndrome, by increasing CO while decreasing filling pressures and pulmonary arterial pressures, without increasing myocardial O2 demand." | 4.77 | Historical perspectives and update of amrinone. ( Goenen, M, 1989) |
| "Circulatory collapse and obtundation occurred in a 37-year-old woman following an iatrogenic overdose of labetalol." | 3.69 | Labetalol overdose successfully treated with amrinone and alpha-adrenergic receptor agonists. ( Kollef, MH, 1994) |
| " Two groups of 15 patients each, suffering from low out-put syndrome, have been studied; patients have been treated with inotropic therapy based on Dobutamina and Amrinone." | 3.68 | [Mixed venous oxygen saturation as optimization of the therapeutic response in low output syndrome]. ( Agrò, C; Costa, P; Gulotta, G; Romano, V; Sansone, A; Sparacia, B, 1991) |
| "The purpose of the present study was to induce left ventricular failure in anesthetized dogs by repeated ventricular fibrillation and then to determine if amrinone is effective in circulatory support by comparing the effects of amrinone and dobutamine." | 3.67 | Comparison of the effects of amrinone and dobutamine on hemodynamics and myocardial oxygen balance in dogs with experimental left ventricular failure. ( Fujigaki, T; Fukui, S; Gotoh, Y; Haseba, S; Miyako, M; Nakamura, H, 1989) |
| "Amrinone by itself is an effective agent to facilitate weaning from CPB, and therapy with amrinone reduced the need for individualized titration of epinephrine." | 2.67 | Amrinone in cardiac surgical patients with left-ventricular dysfunction. A prospective, randomized placebo-controlled trial. ( Butterworth, JF; Lawless, ST; Prielipp, RC; Royster, RL; Wallenhaupt, SL, 1993) |
| "Amrinone was found to be a powerful peripheral vasodilator with a mild positive inotropic action." | 2.67 | Quantitative assessment of the effects of 'inodilators' on the myocardium in patients without primary cardiac insufficiency after coronary surgery: Part I--Amrinone. ( Engel, C; Flameng, W; Geiger, A; Isringhaus, H; Lunkenheimer, PP; Peterschmidt, O; Redmann, K; Rettig, G, 1991) |
| "Amrinone was given so as to increase Cl by at least 30% and to decrease Ppw by at least 30%." | 2.67 | [Hemodynamic effects of amrinone in low cardiac output after mitral valve replacement]. ( Demortiere, P; Estanove, S; George, M; Lehot, JJ, 1991) |
| " A brief review of this institution's preference for amrinone follows, including its pharmacology, side effects, and dosing prior to separation from CPB." | 2.38 | Early intervention of inotropic support in facilitating weaning from cardiopulmonary bypass: the New England Deaconess Hospital experience. ( Lewis, KP, 1993) |
| "Patients with chronic congestive heart failure (CHF) show down-regulation of the beta 1-adrenergic receptor with a decrease in receptor density and altered responses to catecholamines." | 2.38 | Perioperative experience with amrinone. ( Bailey, JM; Levy, JH, 1992) |
| "To illustrate the multiple causes of hypoxemia to be considered following cardiopulmonary bypass and how therapy given to improve oxygen delivery may have contributed to a decrease in arterial oxygen saturation to life-threatening levels." | 1.30 | Profound hypoxemia during treatment of low cardiac output after cardiopulmonary bypass. ( Dennehy, KC; Dupuis, JY; Nathan, HJ; Wynands, JE, 1999) |
| "Amrinone has been shown to have a beneficial effect on left ventricular function in low output syndrome (LOS), but its use after open-heart surgery has not been extensively revised." | 1.28 | Amrinone in perioperative low cardiac output syndrome. ( Fita, G; Gomar, C; Jimenez, MJ; Mulet, J; Nalda, MA; Pacheco, M, 1990) |
| "Amrinone was administered 24 hours postoperatively by bolus injection (2 mg/kg) and by 12-hour infusions (20 micrograms/kg/min)." | 1.27 | Amrinone in the management of low cardiac output after open heart surgery. ( Baele, P; Col, J; Goenen, M; Pedemonte, O, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (35.14) | 18.7374 |
| 1990's | 24 (64.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacGillivray, RG | 1 |
| Shama, DM | 1 |
| Günnicker, M | 4 |
| Brinkmann, M | 1 |
| Donovan, TJ | 1 |
| Freund, U | 2 |
| Schieffer, M | 2 |
| Reidemeister, JC | 3 |
| Kollef, MH | 1 |
| Wynands, JE | 4 |
| Zerkowski, HR | 2 |
| Marggraf, G | 1 |
| Hardy, JF | 1 |
| Belisle, S | 1 |
| Butterworth, JF | 1 |
| Royster, RL | 1 |
| Prielipp, RC | 1 |
| Lawless, ST | 1 |
| Wallenhaupt, SL | 1 |
| Lewis, KP | 1 |
| Husedzinović, I | 1 |
| Rumboldt, Z | 1 |
| Ivancan, V | 1 |
| Nikić, N | 1 |
| Rudeź, I | 1 |
| Biocina, B | 1 |
| Sutlić, Z | 1 |
| Bailey, JM | 3 |
| Miller, BE | 1 |
| Kanter, KR | 1 |
| Tosone, SR | 1 |
| Tam, VK | 1 |
| Kikura, M | 1 |
| Levy, JH | 2 |
| Shanewise, JS | 1 |
| Michelsen, LG | 1 |
| Sadel, SM | 1 |
| Dennehy, KC | 1 |
| Dupuis, JY | 2 |
| Nathan, HJ | 2 |
| Dieterich, HA | 1 |
| Dressler, HT | 1 |
| Doetsch, N | 1 |
| Hakim-Meibodi, K | 1 |
| Lockhart, JD | 1 |
| Bondy, R | 2 |
| Cattran, C | 1 |
| Costa, P | 1 |
| Agrò, C | 1 |
| Sansone, A | 1 |
| Gulotta, G | 1 |
| Romano, V | 1 |
| Sparacia, B | 1 |
| Estafanous, FG | 1 |
| Lathi, KG | 1 |
| Shulman, MS | 1 |
| Diehl, JT | 1 |
| Stetz, JJ | 1 |
| Ramsay, JG | 1 |
| Redmann, K | 1 |
| Lunkenheimer, PP | 1 |
| Isringhaus, H | 1 |
| Rettig, G | 1 |
| Engel, C | 1 |
| Flameng, W | 1 |
| Geiger, A | 1 |
| Peterschmidt, O | 1 |
| DiBianco, R | 1 |
| Lehot, JJ | 1 |
| Demortiere, P | 1 |
| George, M | 1 |
| Estanove, S | 1 |
| Fita, G | 1 |
| Gomar, C | 1 |
| Jimenez, MJ | 1 |
| Pacheco, M | 1 |
| Mulet, J | 1 |
| Nalda, MA | 1 |
| Buser, PT | 1 |
| Auffermann, W | 1 |
| Wu, ST | 1 |
| Jasmin, G | 1 |
| Parmley, WW | 1 |
| Wikman-Coffelt, J | 1 |
| Budny, J | 1 |
| Anderson-Drevs, K | 1 |
| Hess, W | 2 |
| Fujigaki, T | 2 |
| Nakamura, H | 1 |
| Fukui, S | 1 |
| Miyako, M | 1 |
| Haseba, S | 2 |
| Gotoh, Y | 2 |
| Kaplan, JA | 1 |
| Goenen, M | 2 |
| Hines, R | 1 |
| Robinson, RJ | 1 |
| Tchervenkov, C | 1 |
| Nakatsuka, M | 1 |
| Mobley, K | 1 |
| Thormann, J | 1 |
| Kramer, W | 1 |
| Kindler, M | 1 |
| Kremer, P | 1 |
| Schlepper, M | 1 |
| Hashiguchi, Y | 1 |
| Nakahara, I | 1 |
| Yukinari, T | 1 |
| Pedemonte, O | 1 |
| Baele, P | 1 |
| Col, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation: A Randomized, Double-blind, Controlled Trial[NCT05450328] | Phase 2 | 141 participants (Anticipated) | Interventional | 2022-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for amrinone and Cardiac Output, Low
| Article | Year |
|---|---|
The role of amrinone in treating heart failure during and after coronary artery surgery supported by cardiopulmonary bypass.
Topics: Amrinone; Cardiac Output, Low; Cardiopulmonary Bypass; Coronary Artery Bypass; Hemodynamics; Humans; | 1994 |
Inotropic support of the heart that fails to successfully wean from cardiopulmonary bypass: the Montreal Heart Institute experience.
Topics: Adrenergic beta-Agonists; Amrinone; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; | 1993 |
Early intervention of inotropic support in facilitating weaning from cardiopulmonary bypass: the New England Deaconess Hospital experience.
Topics: Amrinone; Boston; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Diabetes Complica | 1993 |
Perioperative experience with amrinone.
Topics: Amrinone; Cardiac Output, Low; Cardiac Surgical Procedures; Heart Failure; Hemodynamics; Humans | 1992 |
The choice of inotropes following cardiopulmonary bypass. Con: amrinone is not a first-choice inotrope following cardiopulmonary bypass.
Topics: Amrinone; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Humans | 1991 |
Historical perspectives and update of amrinone.
Topics: Amrinone; Cardiac Output, Low; Cardiac Surgical Procedures; Humans; Syndrome | 1989 |
Clinical applications of amrinone.
Topics: Amrinone; Blood Pressure; Cardiac Output, Low; Humans; Syndrome; Vascular Resistance | 1989 |
Effects of amrinone on the right side of the heart.
Topics: Amrinone; Cardiac Output, Low; Humans; Hypertension, Pulmonary; Ventricular Function, Right | 1989 |
Amrinone: is it the inotrope of choice?
Topics: Amrinone; Cardiac Output, Low; Drug Utilization; Heart; Humans | 1989 |
7 trials available for amrinone and Cardiac Output, Low
| Article | Year |
|---|---|
The efficacy of amrinone or adrenaline on low cardiac output following cardiopulmonary bypass in patients with coronary artery disease undergoing preoperative beta-blockade.
Topics: Adrenergic beta-Antagonists; Amrinone; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agen | 1995 |
[Concept for therapy of heart failure in heart surgery].
Topics: Amrinone; Cardiac Output, Low; Enoximone; Heart Diseases; Heart Failure; Heart Rate; Heart Transplan | 1994 |
Amrinone in cardiac surgical patients with left-ventricular dysfunction. A prospective, randomized placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Amrinone; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopu | 1993 |
Low-output syndrome after heart surgery: is a monotherapy with phosphodiesterase-III inhibitors feasible? A comparative study of amrinone and enoximone.
Topics: Aged; Amrinone; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Enoximone; | 1992 |
Amrinone and dobutamine as primary treatment of low cardiac output syndrome following coronary artery surgery: a comparison of their effects on hemodynamics and outcome.
Topics: Amrinone; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Coronary Arte | 1992 |
Quantitative assessment of the effects of 'inodilators' on the myocardium in patients without primary cardiac insufficiency after coronary surgery: Part I--Amrinone.
Topics: Adult; Aged; Amrinone; Cardiac Output, Low; Coronary Artery Bypass; Female; Hemodynamics; Humans; Ma | 1991 |
[Hemodynamic effects of amrinone in low cardiac output after mitral valve replacement].
Topics: Adult; Aged; Amrinone; Cardiac Output, Low; Clinical Protocols; Female; Heart Valve Prosthesis; Hemo | 1991 |
21 other studies available for amrinone and Cardiac Output, Low
| Article | Year |
|---|---|
Amrinone, platelets, and the balloon pump.
Topics: Amrinone; Blood Platelets; Cardiac Output, Low; Cardiotonic Agents; Coronary Artery Bypass; Drug The | 1988 |
Labetalol overdose successfully treated with amrinone and alpha-adrenergic receptor agonists.
Topics: Adrenergic alpha-Agonists; Adult; Amrinone; Cardiac Output, Low; Drug Overdose; Female; Humans; Iatr | 1994 |
[Hemodynamic effects of amrinone, dobutamine and dopamine in the cardiac low output syndrome following open-heart surgery].
Topics: Adult; Aged; Aged, 80 and over; Amrinone; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Proc | 1995 |
A comparison of the hemodynamic effects of amrinone and sodium nitroprusside in infants after cardiac surgery.
Topics: Amrinone; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardioto | 1997 |
A bolus dose of 1.5 mg/kg amrinone effectively improves low cardiac output state following separation from cardiopulmonary bypass in cardiac surgical patients.
Topics: Adult; Amrinone; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiac Volume; Cardiopulmonar | 1998 |
Profound hypoxemia during treatment of low cardiac output after cardiopulmonary bypass.
Topics: Amrinone; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Cardiotonic Agents; Dobutamin | 1999 |
[Mixed venous oxygen saturation as optimization of the therapeutic response in low output syndrome].
Topics: Aged; Amrinone; Cardiac Output, Low; Dobutamine; Female; Humans; Male; Oximetry; Oxygen; Syndrome; V | 1991 |
The use of amrinone and norepinephrine for inotropic support during emergence from cardiopulmonary bypass.
Topics: Aged; Amrinone; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cardiopulmonary Bypass; Female; | 1991 |
Reversal of refractory right ventricular failure with amrinone.
Topics: Amrinone; Cardiac Output, Low; Humans; Intra-Aortic Balloon Pumping; Male; Middle Aged; Mitral Valve | 1991 |
Acute positive inotropic intervention: the phosphodiesterase inhibitors.
Topics: Amrinone; Blood Pressure; Cardiac Output, Low; Cardiotonic Agents; Humans; Myocardium; Oxygen Consum | 1991 |
Amrinone in perioperative low cardiac output syndrome.
Topics: Aged; Amrinone; Cardiac Output, Low; Cardiopulmonary Bypass; Female; Hemodynamics; Humans; Male; Mid | 1990 |
Dobutamine potentiates amrinone's beneficial effects in moderate but not in advanced heart failure. 31P-MRS in isolated hamster hearts.
Topics: Amrinone; Animals; Cardiac Output, Low; Cardiomyopathies; Cricetinae; Dobutamine; Drug Combinations; | 1990 |
IV inotropic agents: dopamine, dobutamine, and amrinone.
Topics: Amrinone; Cardiac Output, Low; Critical Care; Dobutamine; Dopamine; Humans; Infusions, Intravenous | 1990 |
Preliminary results with amrinone in perioperative low cardiac output syndrome.
Topics: Aged; Amrinone; Cardiac Output, Low; Coronary Artery Bypass; Dose-Response Relationship, Drug; Femal | 1987 |
Comparison of the effects of amrinone and dobutamine on hemodynamics and myocardial oxygen balance in dogs with experimental left ventricular failure.
Topics: Amrinone; Animals; Blood Pressure; Cardiac Output, Low; Coronary Circulation; Coronary Disease; Dobu | 1989 |
Amrinone: contemporary management of the low cardiac output syndrome. Introduction.
Topics: Amrinone; Cardiac Output, Low; Digitalis Glycosides; Diuretics; Humans; Syndrome; Vasodilator Agents | 1989 |
Treatment of low cardiac output after aortocoronary artery bypass surgery using a combination of norepinephrine and amrinone.
Topics: Aged; Amrinone; Cardiac Output, Low; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Male | 1987 |
The combined use of noradrenaline, amrinone and nitroglycerin in the management of severe low cardiac output after coronary artery surgery.
Topics: Amrinone; Cardiac Output, Low; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Male; Midd | 1988 |
[Determination of active components of amrinone by analysis of pressure-volume results; use of the conductance (volume) catheter technic and rapid load change by balloon occlusion of the inferior vena cava].
Topics: Amrinone; Cardiac Catheterization; Cardiac Output, Low; Cardiomyopathy, Dilated; Dobutamine; Drug Th | 1987 |
[The effects of amrinone on hemodynamics and myocardial oxygen balance in anesthetized dogs with experimental left ventricular failure by ventricular fibrillation].
Topics: Amrinone; Animals; Cardiac Output, Low; Dogs; Heart; Hemodynamics; Oxygen Consumption; Ventricular F | 1987 |
Amrinone in the management of low cardiac output after open heart surgery.
Topics: Adult; Aged; Aminopyridines; Amrinone; Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedu | 1985 |