amrinone has been researched along with Cardiac Hypertrophy in 3 studies
Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When congestive heart failure supervenes, the prognosis is poor." | 2.37 | Central and peripheral components of cardiac failure. ( Factor, S; Le Jemtel, TH; Mancini, DM; Sonnenblick, EH, 1986) |
| "These findings suggest that in chronic cardiac hypertrophy, contractile responses to phosphodiesterase inhibitors may be preserved despite marked reductions in inotropic responses to beta-adrenoceptor agonists." | 1.33 | Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. ( Norton, G; Osadchii, O; Woodiwiss, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osadchii, O | 1 |
| Norton, G | 1 |
| Woodiwiss, A | 1 |
| Mancini, DM | 1 |
| Le Jemtel, TH | 1 |
| Factor, S | 1 |
| Sonnenblick, EH | 1 |
| Bradley, AB | 1 |
| Baim, DS | 1 |
2 reviews available for amrinone and Cardiac Hypertrophy
| Article | Year |
|---|---|
Central and peripheral components of cardiac failure.
Topics: Aminopyridines; Amrinone; Animals; Captopril; Cardiac Output; Cardiomegaly; Cardiotonic Agents; Cate | 1986 |
Measurement of coronary blood flow in man: methods and implications for clinical practice.
Topics: Amrinone; Angina Pectoris; Animals; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary V | 1985 |
1 other study available for amrinone and Cardiac Hypertrophy
| Article | Year |
|---|---|
Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Animals; Blood Pressure; Cardiomegaly; Cardiotonic | 2005 |