Page last updated: 2024-10-22

amprolium and Neuroblastoma

amprolium has been researched along with Neuroblastoma in 3 studies

Amprolium: A veterinary coccidiostat that interferes with THIAMINE metabolism.
amprolium : An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.
amprolium(1+) : A pyridinium ion that is the cationic portion of amprolium, a veterinary drug which is used for prevention of coccidiosis in poultry and cattle.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" Therefore, the aim of our work was to find out how amprolium-induced thiamine pyrophosphate deficits (TD) affect distribution of acetyl-CoA in the compartment of pure cholinergic neuroblastoma SN56 cells originating from murine septum."7.77Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells. ( Bielarczyk, H; Bizon-Zygmańska, D; Jankowska-Kulawy, A; Marszałł, M; Pawełczyk, T; Ronowska, A; Szutowicz, A, 2011)
"Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i."7.69Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine. ( Bettendorff, L; Goessens, G; Grisar, T; Sluse, F; Wins, P, 1995)
"When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days."7.69Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors. ( Bettendorff, L; Bureau, M; Goessens, G; Grisar, T; Laschet, J; Sluse, F; Wins, P, 1995)
" Therefore, the aim of our work was to find out how amprolium-induced thiamine pyrophosphate deficits (TD) affect distribution of acetyl-CoA in the compartment of pure cholinergic neuroblastoma SN56 cells originating from murine septum."3.77Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells. ( Bielarczyk, H; Bizon-Zygmańska, D; Jankowska-Kulawy, A; Marszałł, M; Pawełczyk, T; Ronowska, A; Szutowicz, A, 2011)
"Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i."3.69Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine. ( Bettendorff, L; Goessens, G; Grisar, T; Sluse, F; Wins, P, 1995)
"When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days."3.69Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors. ( Bettendorff, L; Bureau, M; Goessens, G; Grisar, T; Laschet, J; Sluse, F; Wins, P, 1995)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bizon-Zygmańska, D1
Jankowska-Kulawy, A1
Bielarczyk, H1
Pawełczyk, T1
Ronowska, A1
Marszałł, M1
Szutowicz, A1
Bettendorff, L2
Sluse, F2
Goessens, G2
Wins, P2
Grisar, T2
Bureau, M1
Laschet, J1

Other Studies

3 other studies available for amprolium and Neuroblastoma

ArticleYear
Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells.
    Neurochemistry international, 2011, Volume: 59, Issue:2

    Topics: Acetyl Coenzyme A; Amprolium; Cell Line, Tumor; Humans; Immunohistochemistry; Neuroblastoma; Thiamin

2011
Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: Amprolium; Microscopy, Electron; Mitochondria; Necrosis; Neuroblastoma; Thiamine; Thiamine Deficienc

1995
Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors.
    Journal of neurochemistry, 1995, Volume: 64, Issue:5

    Topics: Adenosine Triphosphate; Amprolium; Animals; Cell Death; Culture Media; Isoquinolines; Lactates; Lact

1995
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