amphotericin-b and Tongue-Neoplasms

Histoplasmosis, though usually a silent pulmonary infection, may progress to a severe, sometimes fatal disseminated infection. In the chronic form of disseminated histoplasmosis, granulomatous lesions of the upper aerodigestive tract are common. These lesions can be mistaken for carcinoma on initial presentation, as in the case we have presented here. The clinical course of patients with acute, subacute, or chronic disseminated forms of this disease correlates well with the histopathologic findings. Diagnosis is best made by culture or biopsy of a characteristic lesion. Although amphotericin B remains the standard treatment of disseminated histoplasmosis, the imidazole compounds such as ketoconazole, either alone or in combination with amphotericin B, have also been shown to be effective.

Topics: Adult; Amphotericin B; Child; Chronic Disease; Diagnosis, Differential; Histoplasmosis; Humans; Infant; Ketoconazole; Male; Middle Aged; Tongue Diseases; Tongue Neoplasms

Candidemia is an opportunistic infection caused primarily by Candida albicans. We experienced a case of severe Candidemia that developed after surgical treatment for tongue cancer and required considerable labor to diagnose and to treat, though no particular immunodeficiency was seen before. The case was resistant to an antifungal agent, fluconazole, but was successfully treated with amphotericin B. Positive blood cultures, local wound culture, and increased β;-D-glucan were useful to diagnose the infection. In particular, gallium-67 scintigraphy was remarkably useful for the diagnosis and the evaluation of therapeutic effects in this case. Development of Candidemia following an oral and maxillofacial surgery is extremely rare among young adults, thus this case report serves to draw attention to the risk in oral and maxillofacial surgery.

Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Drug Resistance, Fungal; Fluconazole; Gallium Radioisotopes; Humans; Postoperative Complications; Radionuclide Imaging; Tongue Neoplasms; Treatment Outcome; Young Adult

Topics: Aged; Amphotericin B; Animals; Diagnosis, Differential; Histoplasma; Histoplasmosis; Humans; Liver; Male; Mice; Spleen; Tongue; Tongue Neoplasms

Topics: Amphotericin B; Candidiasis; Foot Dermatoses; Humans; Male; Middle Aged; Penicillins; Tongue Neoplasms

Topics: Amphotericin B; Candidiasis; Gastrointestinal Tract; Humans; Sepsis; Tongue Neoplasms