amphotericin-b and Testicular-Diseases

The goal of the present study was to characterize the semen quality of dogs naturally infected with Leishmaniachagasi, and treated with Allopurinol and Amphotericin B. Eight naturally infected and eight non-infected dogs were selected. Following semen collection, progressive motility, vigor, concentration and sperm morphology were evaluated. The seminal patterns in the treated animals were evaluated at the beginning (d0) and at days 30 (d30), 60 (d60) and 150 (d150) of treatment. The progressive motility at d0 (35.7+/-22.3%) was less than that of the control group (77.8+/-7.1%) (P<0.05). The vigor was similar to the control group throughout the treatment (P>0.05). The number of sperm/mL, sperm/ejaculate and sperm/kg of body weight was similar among groups (P>0.05). The percentages of normal spermatozoa of infected and treated animals were similar throughout the treatment and to the control group (69.1+/-8.7%) at d60 (37.5+/-11.2%) and d150 (48.3+/-10.8%) (P>0.05), but smaller at d0 (22.7+/-10.5%) and d30 (28.8+/-15.9%) (P<0.05). A greater percentage of acrosome damage was observed in the control group (3.1+/-2.3%) compared to the d60 (0.1+/-0.2%) (P<0.05). The infected dogs had a greater percentage of principal piece defects at d60 (37.0+/-6.3%) than the control group (16.8+/-7.3%) (P<0.05); and greater percentages of detached normal heads at d0 (28.7+/-19.7%) and d30 (18.5+/-18.5%) than the control group (0.4+/-0.5%) (P<0.05). This reduction in semen quality of the infected animals is suggestive of an epididymal dysfunction. Due to this poor semen quality, caution is recommended when using infected male dogs for reproductive purposes.

Topics: Acrosome; Allopurinol; Amphotericin B; Animals; Antiprotozoal Agents; Dog Diseases; Dogs; Epididymis; Leishmaniasis, Visceral; Male; Sperm Count; Sperm Motility; Spermatozoa; Testicular Diseases

Reported herein is the first Brazilian case of epididymal involvement by South American blastomycosis, and apparently the second case to be reported in the world literature.

Topics: Amphotericin B; Brazil; Epididymis; Humans; Male; Middle Aged; Paracoccidioidomycosis; Sulfonamides; Testicular Diseases

In a retrospective study of 51 cases of systemic North American blastomycosis 11 patients were found to have genitourinary tract involvement, the prostate and epididymis being most commonly affected. Diagnosis was made by culture of the fungus from urine, abscess or prostate secretions, morphologic identification of the characteristic organism in urine or secretions, or histologic examination of tissue specimens. Treatment with amphotericin B reduced the mortality rate of 90 per cent to as low as 10 per cent. Long-term followup is necessary because of a relapse rate of 10 to 15 per cent.

Topics: Adult; Aged; Amphotericin B; Blastomycosis; Epididymitis; Genital Diseases, Male; Humans; Kidney Diseases; Male; Middle Aged; Penile Diseases; Potassium Iodide; Prostatic Diseases; Stilbamidines; Testicular Diseases

Topics: Amphotericin B; Blastomycosis; Humans; Male; Middle Aged; Skin Diseases; Testicular Diseases

Topics: Aminosalicylic Acids; Amphotericin B; Blastomycosis; Coitus; Endometritis; Epididymis; Fallopian Tubes; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Isoniazid; Lung; Male; Middle Aged; Peritoneal Diseases; Prostatic Diseases; Radiography; Sexually Transmitted Diseases; Testicular Diseases; Urogenital System; Urologic Diseases; Uterine Diseases