amphotericin-b and Stomach-Ulcer

Topics: Aged; Amphotericin B; Antifungal Agents; Biopsy; Cardia; Emergency Service, Hospital; Endoscopy, Digestive System; Female; Humans; Mucormycosis; Stomach Ulcer

Gastric mucormycosis is a rare and life-threatening fungal disease, caused by fungus in the order Mucorales. While rhino-cerebral and pulmonary forms are common, gastric mucormycosis is an uncommon site for the disease. We diagnosed gastric mucormycosis in a 41-year-old female who had severe multiple trauma, including cardiac rupture, due to a traffic accident. Eighteen days after hospitalization, she passed 800 mL of melena over one day. We performed upper esophagogastroduodenoscopy (EGD) and found a huge gastric ulcer with bleeding. Histopathological examination identified non-septated and right-angled branching fungal hyphae, and we diagnosed gastric mucormycosis. We recommended total gastrectomy to her but she refused the operation, so she was treated with liposomal amphotericin B for 53 days. After two months of treatment with liposomal amphotericin B, we again performed EGD and found a healed gastric ulcer. After four months, with another EGD, we found that the gastric mucormycosis was completely healed.

Topics: Abdomen; Adult; Amphotericin B; Endoscopy, Digestive System; Female; Heart Injuries; Humans; Mucorales; Mucormycosis; Stomach Ulcer; Tomography, X-Ray Computed

Topics: Amphotericin B; Antifungal Agents; Female; Gastroscopy; Humans; Middle Aged; Mucormycosis; Stomach Ulcer

Topics: Abdominal Pain; Amphotericin B; Biopsy, Needle; Color; Follow-Up Studies; Gastroscopy; Humans; Immunohistochemistry; Male; Middle Aged; Mucormycosis; Risk Assessment; Severity of Illness Index; Stomach Ulcer; Tomography, X-Ray Computed; Treatment Outcome

Gastric zygomycosis is a rare but potentially lethal complication in transplant patients. Forty-two cases of gastric mucormycosis have been described in the literature, with a mortality of 98%.. We report of a case of gastric mucormycosis in a 45-year-old male undergoing liver transplantation for alcohol-induced cirrhosis. The diagnosis was made 20 days after transplantation in a biopsy of a bleeding gastric ulcer identified during a reoperation for a common bile duct stricture.. After the surgical procedure and therapy with amphotericin B, the patient made a good recovery and is alive and well 2 years after transplantation.. Gastric mucormycosis should be suspected in those patients in whom gastrointestinal symptoms such a pain or bleeding are present. Because the diagnosis is dependent on histology, the importance of biopsy cannot be underestimated. Once diagnosed, a successful outcome depends on effective treatment with amphotericin.

Topics: Amphotericin B; Antifungal Agents; Biopsy; Follow-Up Studies; Gastrointestinal Diseases; Humans; Liver Cirrhosis, Alcoholic; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Reoperation; Stomach Ulcer; Time Factors; Treatment Outcome; Zygomycosis

Fungal cells were observed infiltrating the submucosal margins of an acutely perforated gastric ulceration in an apparently immunocompetent 3-year-old girl. Perforation had occurred 24 h after hospital admission because of pain and vomiting. Colonies of Candida tropicalis were grown from peritoneal fluid and blood cultures. After surgical repair and a 30-day treatment with amphotericin B at a daily dose of 1 mg kg-1 body weight, the child was discharged in good health. No further infections have occurred in the 3 years since treatment.

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Child, Preschool; Emergency Service, Hospital; Female; Humans; Immunocompetence; Male; Pain; Rupture, Spontaneous; Stomach Rupture; Stomach Ulcer; Vomiting

Candida infection of mild gastric ulcers was detected by gastric biopsy in 6 patients aged from 67 to 82 years. Filaments and spores were located in the connective tissue or submucosa in 3 cases and in the false membrane in the other 3. No predisposing cause was found in 5 patients. Chemical study of the gastric secretion was performed in all patients under maximal pentagastrin stimulation and showed normal acidity. The addition of amphotericin B to the anti-ulcerous treatment seems to have helped the ulcer to heal.

Topics: Aged; Amphotericin B; Candidiasis; Endoscopy; Female; Humans; Periodic Acid-Schiff Reaction; Stomach Ulcer

Three children with the rare occurrence of zygomycosis are descibed: two had involvement of a solitary lesion of gangrenous cellulitis on the buttocks, and th third was a neonate with gastric performation and a gangrenous appendicitis. All three patients were compromised hosts (two with leukemia and one a premature infant with respiratory distress syndrome). All three patients appeared to have acquired the same organism. Rhizopus oryzae, from the same fomites, elastic bondages (Elastoplast). The Center for Disease Control has received several other reports of zygomycosis traceable to the same material. Alll three of our patients were cured of their infections. Early diagnosis and a combined surgical and chemotherapeutic approach appear to prevent death from zygomycosis.

Topics: Amphotericin B; Appendicitis; Bandages; Cellulitis; Child; Female; Humans; Infant, Newborn; Leukemia, Lymphoid; Male; Mucormycosis; Peptic Ulcer Perforation; Respiratory Distress Syndrome, Newborn; Rhizopus; Stomach Ulcer

A case is presented of ascites infected with candida in a cirrhotic patient. Candida infection of the ascitic fluid and candidemia were found 24 hours after perforation of a gastric ulcer. Combined intravenous therapy with Amphotericin B and 5-Fluorocytosine eradicated the infection within two weeks. The need for comprehensive therapeutic approach in the debilitated patient prone to fungal and bacterial infection is emphasized.

Topics: Aged; Amphotericin B; Ascites; Candidiasis; Flucytosine; Humans; Male; Peptic Ulcer Perforation; Stomach Ulcer

Two cases of candidiasis occured in the stomach. The first is a case of disseminated candidiasis with stomach wall involvement. The patient had Hodgkin's disease and responded to chemotherapy and amphotericin B. The second is a case of superficial invasion of Candida in a stitch ulcer. Systemic and local factors influence growth of Candida in the stomach.

Topics: Aged; Amphotericin B; Candida; Candidiasis; Female; Gastritis; Gastrointestinal Hemorrhage; Hodgkin Disease; Humans; Male; Middle Aged; Stomach Ulcer; Sutures

Topics: Aged; Amphotericin B; Biopsy; Diagnosis, Differential; Gastrectomy; Gastric Juice; Gastric Lavage; Gastric Mucosa; Humans; Male; Mucor; Mucormycosis; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer

Topics: Adult; Aged; Amphotericin B; Anti-Bacterial Agents; Candida albicans; Candidiasis; Child, Preschool; Female; Humans; Intestinal Perforation; Male; Middle Aged; Peritonitis; Quadriplegia; Stomach Ulcer

Topics: Adult; Amphotericin B; Ascites; Candida; Candidiasis; Diagnosis, Differential; Diagnostic Errors; Humans; Liver Cirrhosis; Male; Peptic Ulcer Perforation; Peritonitis; Radiography; Stomach Ulcer