amphotericin-b and Stevens-Johnson-Syndrome

Topics: Administration, Topical; Amphotericin B; Anemia, Aplastic; Anti-Infective Agents; Benzamidines; Chronic Disease; Conjunctivitis; Conjunctivitis, Allergic; Corneal Injuries; Dermatitis, Contact; Drug Eruptions; Epithelium; Humans; Idoxuridine; Keratitis; Stevens-Johnson Syndrome; Sulfonamides; Wound Healing

Topics: Amphotericin B; Anti-Bacterial Agents; Humans; Male; Metronidazole; Middle Aged; Stevens-Johnson Syndrome

Topics: Adult; Amphotericin B; Anti-HIV Agents; Female; Histamine Antagonists; HIV Infections; Humans; Leishmaniasis, Visceral; Stevens-Johnson Syndrome

To report a case of fungal keratitis of the eye caused by Pichia anomala in a patient with systemic lupus erythematous and Stevens-Johnson syndrome.. This was a retrospective chart review.. A 50-year-old woman with systemic lupus erythematosus presented with ocular pain of 4-day duration. Culture of corneal scrapings was positive for P. anomala. Clinically, the organism appeared to respond to topical natamycin, amphotericine B, and oral itraconazole.. A rare case of P. anomala-associated keratitis was successfully treated with topical amphotericin B, natamycin, and systemic inidazole.

Topics: Amphotericin B; Antifungal Agents; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Fungal; Female; Humans; Imidazoles; Lupus Erythematosus, Systemic; Middle Aged; Mycoses; Natamycin; Pichia; Stevens-Johnson Syndrome

Generalized cryptococcosis with CNS involvement was diagnosed in a 3-year-old spayed German Shorthaired Pointer. Clinical findings included Horner's syndrome, generalized lymphadenopathy, temporal muscle atrophy, and chorioretinitis. Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B. After discontinuation of the 5-fluorocytosine and amphotericin B and treatment with cephradine and ketoconazole, the toxic epidermal necrolysis resolved. Treatment was completed without further complication by using amphotericin B and ketoconazole concurrently.

Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Flucytosine; Ketoconazole; Stevens-Johnson Syndrome