amphotericin-b and Skin-Manifestations

A patient who has had three distinct recurrences of disseminated histoplasmosis over 22 years is presented. Measurements of cellular and humoral immune response to histoplasmin antigens were compared with previously reported data. Although initially sulfisoxazole therapy led to regression of disease, over the past 13 years she has required three courses of amphotericin B, each time with resolution of signs and symptoms. Despite minimal evidence of a cellular or humoral immune response to this organism, the patient has done well. Although disseminated histoplasmosis is often a fatal disease, this woman has tolerated the infection well.

Topics: Adult; Amphotericin B; Antibody Formation; Female; Histoplasmosis; Humans; Immunity, Cellular; Mouth Diseases; Pharyngeal Diseases; Recurrence; Skin Manifestations; Sulfisoxazole

We present a case of histoplasmosis with skin manifestations occurring 17 years after initial diagnosis. The clinical manifestations of disseminated disease are discussed. Amphotericin B administered through an A-V shunt resulted in prompt resolution of the skin lesions.

Topics: Aged; Amphotericin B; Arteriovenous Shunt, Surgical; Histoplasmosis; Humans; Lung Diseases, Fungal; Male; Skin Manifestations

Topics: Adult; Amphotericin B; Cell Migration Inhibition; Chlorella; Complement System Proteins; Fluorescent Antibody Technique; Hepatitis; Humans; Immunity, Maternally-Acquired; Immunodiffusion; Immunoglobulins; Immunotherapy; Infections; Injections, Intravenous; Lymphocyte Activation; Male; Skin Manifestations

Topics: Adult; Amphotericin B; Congo; Hip Joint; Histoplasma; Histoplasmosis; Humans; Joint Diseases; Lung Diseases, Fungal; Lymphatic Diseases; Male; Shoulder Joint; Skin Manifestations

Topics: Amphotericin B; Biopsy; Histoplasma; Histoplasmin; Histoplasmosis; Humans; Lymphatic Diseases; Male; Precipitin Tests; Radiography, Thoracic; Senegal; Skin Manifestations; Skin Tests

Topics: Amphotericin B; Candidiasis; Diabetes Complications; Diabetic Angiopathies; Foot Diseases; Glucose; Griseofulvin; Humans; Injections, Intramuscular; Nystatin; Pyoderma; Skin Diseases; Skin Manifestations; Skin Ulcer; Tolnaftate; Xanthomatosis

Topics: Adult; Amphotericin B; Eye Manifestations; Eyelids; Humans; Injections, Intravenous; Male; Mastoiditis; Middle Aged; Mucor; Mucormycosis; Otitis Media; Rhinitis; Skin Manifestations

Topics: Amphotericin B; Biopsy; Histoplasma; Histoplasmosis; Humans; Male; Middle Aged; Prostatic Diseases; Radiography; Seminal Vesicles; Skin Diseases; Skin Manifestations

Topics: Amphotericin B; Autopsy; Child; Chloramphenicol; Cryptococcosis; Hodgkin Disease; Humans; Hydrocortisone; Male; Salmonella Infections; Skin Manifestations; Spinal Diseases

Topics: Adult; Amphotericin B; Cryptococcosis; Female; Humans; Pleural Effusion; Sarcoidosis; Skin Manifestations

Topics: Adolescent; Adult; Age Factors; Aged; Amphotericin B; Black People; Blastomycosis; Child; Female; Follow-Up Studies; Humans; Iodides; Kentucky; Male; Middle Aged; Prognosis; Skin Manifestations; Stilbamidines; Tuberculosis, Pulmonary; White People

Topics: Amphotericin B; Animals; Cryptococcosis; Dog Diseases; Dogs; Skin Manifestations

Topics: Amphotericin B; California; Coccidioidomycosis; Drug Therapy; Epidemiology; Fungi; Humans; Lung Diseases, Fungal; Radiography, Thoracic; Skin Manifestations

Topics: Amphotericin B; Blastomycosis; Diagnosis; Drug Therapy; Epidemiology; Humans; Radiography, Thoracic; Skin Manifestations; Stilbamidines; Toxicology; United States