amphotericin-b and Shock

Bloodstream infections due to Candida spp. are associated with significant mortality and morbidity. This study analysed the epidemiology and outcome of candidemia cases in a teaching hospital in central Taiwan.. We retrospectively studied the clinical characteristics and antifungal susceptibility of isolates and risk factors for mortality in 91 cases of candidemia treated from January 1, 2001 to June 30, 2003.. The mean age of the patients was 67 years (range, 30-90 years). Three episodes (3%) were community acquired. Adequate antifungal therapy was given to 78 patients (78%). Cancer (38.5%) and diabetes mellitus (36.3%) were the 2 most common underlying diseases. The most frequent risk factors identified for candidemia were prior broad-spectrum antibiotic use (84.6%), central venous catheterization (83.5%) and Candida colonization (79.5%). The most frequent isolates were Candida albicans (64.8%) and Candida tropicalis (19.8%). All of the C. albicans and C. tropicalis isolates were sensitive to fluconazole (minimal inhibitory concentration

Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Anti-Bacterial Agents; APACHE; Candida; Candidiasis; Catheterization, Central Venous; Community-Acquired Infections; Cross Infection; Diabetes Complications; Female; Fluconazole; Fungemia; Hospitals; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Neoplasms; Prognosis; Retrospective Studies; Risk Factors; Shock; Statistics as Topic; Taiwan

Topics: Adolescent; Amphotericin B; Anti-Bacterial Agents; Bone Marrow Transplantation; Fever; Humans; Male; Rhabdomyolysis; Shock; Transplantation, Homologous

Topics: Amphotericin B; Candidiasis; Coma; Diabetes Complications; Female; Fever; Humans; Middle Aged; Shock