amphotericin-b and Rhabdomyolysis

Topics: Adolescent; Adult; Amphotericin B; Antiprotozoal Agents; Bangladesh; Child; Female; Humans; Hypokalemia; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Rhabdomyolysis; Young Adult

Hypokalemia can result in life-threatening complications if not treated appropriately. Although hypokalemia is a frequent adverse effect of amphotericin B therapy, there are no reports in the pediatric literature on hypokalemia-associated rhabdomyolysis induced by this drug. A ten-year-old boy with a history of one week amphotericin B treatment was admitted with weakness of the lower extremities, inability to walk and calf pain. Laboratory tests showed a serum potassium of 1.7 mEq/L and a serum creatinine phosphokinase of 3937 U/L plus myoglobulinuria. Following fluid expansion and intravenous potassium replacement, the patient progressed to achieve full regression of muscular weakness after one week. This report highlights hypokalemia as a rare cause of rhabdomyolysis. Patients on amphotericin B should be checked for this rare yet potentially life-threatening complication.

Topics: Amphotericin B; Anti-Bacterial Agents; Child; Follow-Up Studies; Humans; Hypokalemia; Male; Rhabdomyolysis; Surgical Wound Infection

Topics: Adolescent; Amphotericin B; Anti-Bacterial Agents; Bone Marrow Transplantation; Fever; Humans; Male; Rhabdomyolysis; Shock; Transplantation, Homologous