amphotericin-b and Retinitis

Topics: Amphotericin B; Antifungal Agents; Basidiomycota; Blast Crisis; Caspofungin; Cerebrospinal Fluid; Child; Drug Therapy, Combination; Eye Infections, Fungal; Fatal Outcome; Female; Fungemia; Humans; Leukemia, Myeloid, Acute; Retinitis; Trichosporonosis; Voriconazole

This study aimed to highlight the association of stellate neuroretinitis occurring secondary to endogenous candidemia.. We report an unusual presentation of endogenous Candida endophthalmitis as a stellate neuroretinitis in the setting of Cornelia de Lange syndrome.. A 34-month-old girl with severe Cornelia de Lange syndrome and a history of parenteral nutrition dependence requiring a chronic central venous catheter presented with bilateral endophthalmitis secondary to candidemia. In one eye, the endophthalmitis had the atypical presentation as a stellate neuroretinitis.. This case represents a unique association of stellate neuroretinitis secondary to Candida infection in a patient with Cornelia de Lange syndrome.

Topics: Administration, Ophthalmic; Amphotericin B; Antifungal Agents; Bacteremia; Candida albicans; Candidemia; Candidiasis; Child, Preschool; De Lange Syndrome; Endophthalmitis; Eye Infections, Fungal; Female; Humans; Intravitreal Injections; Klebsiella; Klebsiella Infections; Retinitis; Voriconazole

Topics: Administration, Oral; Adult; Amphotericin B; Antifungal Agents; Choroiditis; Cryptococcosis; Cryptococcus gattii; Drug Therapy, Combination; Eye Diseases; Eye Infections, Fungal; Fluconazole; Flucytosine; HIV Infections; Humans; Infusions, Intravenous; Male; Meningitis, Cryptococcal; Retinitis; Tomography, Optical Coherence; Vitreous Body

The authors describe a case of bilateral acute necrotizing retinitis caused by Aspergillus fumigatus in an immunocompromised host. The patient rapidly lose useful vision and expired from progressive systemic disease while on parenteral amphotericin B. Postmortem aqueous cultures were negative whereas vitreous cultures were positive. Light and electron microscopy demonstrated marked choroidal and retinal vascular occlusion by fungi and thrombi, hyphae extending through vessel walls and the internal limiting membrane of the retina, fungi accumulating in tissue spaces, hyphae on the iris surface, and necrosis of the retina. In view of the extensive vascular occlusion present in this disease, early diagnostic vitrectomy plus intravitreal amphotericin B is recommended to deliver adequate drug levels to infected sites.

Topics: Amphotericin B; Aspergillosis; Aspergillus fumigatus; Biopsy; Eye Enucleation; Humans; Male; Middle Aged; Retina; Retinitis; Visual Acuity; Vitreous Body

Endogenous Aspergillus flavus endophthalmitis with layering of inflammatory cells in the subretinal space and vitreous infiltration developed in a 35-year-old female intravenous drug abuser. The patient underwent a diagnostic and therapeutic vitrectomy within 48 hours of presentation, receiving intravitreal amphotericin B. Intravenous amphotericin also was administered several days later. Despite extensive retinal and vitreous involvement, the patient recovered useful vision because of the aggressive diagnostic and therapeutic approach.

Topics: Adult; Amphotericin B; Aspergillosis; Aspergillus flavus; Endophthalmitis; Female; Fundus Oculi; Humans; Injections, Intravenous; Retinitis; Substance-Related Disorders; Visual Acuity; Vitrectomy

A 33-year-old man was treated with systemic steroids for a retinal inflammatory lesion before the diagnosis of cryptococcal retinitis and meningitis was suspected. He died from central nervous system disease despite treatment with parenteral antifungals. Histopathological studies demonstrated ocular and disseminated systemic infection with Cryptococcus neoformans. Direct cryptococcal involvement of the eye is rare and is usually associated with disseminated disease. Systemic steroids must be used with caution, and patients who take these drugs require frequent monitoring.

Topics: Adult; Amphotericin B; Cryptococcosis; Flucytosine; Fundus Oculi; Humans; Male; Meningitis; Prednisone; Retina; Retinitis

Bare lymphocyte syndrome (BLS) is a rare, severe combined immunodeficiency characterized by lack of expression of HLA A, B and C antigens and the absence of B2 microglobulins. Patients with BLS exhibit functional deficiency of both T and B cells resulting in bacterial as well as viral and fungal infection. Ophthalmic findings in this group of disorders have not been reported. We present a case of candida retinitis in a terminally ill 5-year-old girl with BLS.

Topics: Amphotericin B; Candidiasis; Child, Preschool; Female; Humans; Immunologic Deficiency Syndromes; Retinitis

Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Disease Models, Animal; Drug Therapy, Combination; Endophthalmitis; Fluorescein Angiography; Imidazoles; Injections, Intravenous; Ketoconazole; Miconazole; Microbial Sensitivity Tests; Piperazines; Rabbits; Retinitis; Time Factors

Topics: Amphotericin B; Blood; Candida; Candida albicans; Candidiasis; Catheterization; Diverticulitis, Colonic; Endophthalmitis; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Postoperative Complications; Retinitis; Sepsis

Topics: Adolescent; Adult; Amphotericin B; Candidiasis; Catheterization; Chorioretinitis; Choroiditis; Female; Flucytosine; Humans; Macula Lutea; Male; Middle Aged; Ophthalmoscopy; Postoperative Complications; Retinitis; Sepsis

Topics: Adult; Amphotericin B; Candidiasis; Candidiasis, Oral; Exudates and Transudates; Flucytosine; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Male; Retinitis

Topics: Adult; Amphotericin B; Conjunctiva; Cryptococcosis; Cryptococcus; Eye Diseases; Fundus Oculi; Humans; Lupus Erythematosus, Systemic; Male; Meningitis; Necrosis; Optic Nerve; Papilledema; Prednisone; Pupil; Retina; Retinitis

Topics: Amphotericin B; Coccidioidomycosis; Humans; Male; Middle Aged; Retinitis

Topics: Amphotericin B; Antifungal Agents; Chorioretinitis; Histoplasmosis; Retinitis; Uveitis