amphotericin-b and Respiration-Disorders

We describe 16 HIV-infected patients with disseminated histoplasmosis (14 men, mean age 28 +/- 7.84 years), diagnosed at Hospital Eva Perón in Argentina during the period of October 1993 to July 2000. Disseminated histoplasmosis occurred in 5.3% of HIV-infected patients over the study period. The main symptoms included fever, weight loss and hepatosplenomegaly in 93.8%. Other relevant findings were respiratory compromise (56.3%), digestive symptoms (43.8%), mucocutaneous lesions (75%) and multiple lymphadenopathy (69%). Treatment consisted of amphotericin B 1 mg/kg/day up to a total dose of 1 g, followed by 400 mg/day of oral itraconazole. Mortality in the acute phase was 19% and 37.5% of patients relapsed.

Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Argentina; Female; Fever; Fluconazole; Hepatomegaly; Histoplasmosis; Humans; Itraconazole; Male; Recurrence; Respiration Disorders; Splenomegaly; Weight Loss

Topics: Amphotericin B; Antifungal Agents; Candidiasis; Deoxycholic Acid; Drug Combinations; Humans; Male; Middle Aged; Phosphatidylcholines; Phosphatidylglycerols; Respiration Disorders