amphotericin-b and Remission--Spontaneous

Mucormycosis is a rare and fatal opportunistic infection occurring in severely immunocompromised patients. Here, we report, for the first time, on a 65-year-old man with idiopathic membranous nephropathy and moderate renal dysfunction who suffered from life-threatening pulmonary mucormycosis during immunosuppressive therapy. After amphotericin B (AmB) administration with a total accumulating dose of 1.5 g, not only has he recovered from this fatal infection, but also his nephrotic syndrome has entered complete and long-term remission without any continued corticosteroid and immunosuppressive therapy during the 6-year follow-up. Serum creatinine levels remained stable by adjusting the tolerable daily dose of AmB during the period of treatment.

Topics: Aged; Amphotericin B; Antifungal Agents; Glomerulonephritis, Membranous; Humans; Immunosuppression Therapy; Male; Mucormycosis; Nephrotic Syndrome; Remission, Spontaneous

We present a full-term female infant with congenital candidiasis characterized by extensive vesicular and pustular skin lesions associated with pneumonia and severe respiratory distress that appeared during the first hours after birth. The patient was born by cesarean section with no history of rupture of membranes. The mother had a vaginal discharge 3 weeks before delivery. The diagnosis was made by culture of pustular fluid, which grew Candida albicans. Systemic cultures were negative. The infant required a very brief course of conventional mechanical ventilation in spite of impressive and extensive lung infiltrates on the chest radiograph. She made a very quick clinical recovery although it is remarkable that antifungal treatment with amphotericin B was begun very late in her clinical course at the time when she was showing obvious signs of major improvement. Current management guidelines strongly recommend specific therapy for infants with invasive congenital candidiasis or with burn-like extensive dermatitis even without lung involvement. We are not suggesting any change in these recommendations; however, at least in our patient, when amphotericin B was started, she was clearly recovering; it seems possible that her disease although extensive might have experienced an unusual spontaneous regression. This case can provide further insights into this unusual neonatal infection.

Topics: Amphotericin B; Candidiasis; Candidiasis, Cutaneous; Female; Humans; Infant, Newborn; Lung Diseases, Fungal; Pneumonia; Remission, Spontaneous

We present serial radiographic and CT findings of spontaneous reversibility of "pleural thickening" in a patient with proved semi-invasive pulmonary aspergillosis who developed bilateral intracavitary aspergillomas. To the best of our knowledge, this is the first report in the literature of this feature. Radiologists should be aware that pleural thickening in patients with semi-invasive aspergillosis does not necessarily indicate irreversible pleural fibrosis.

Topics: Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Bronchoalveolar Lavage Fluid; Bronchoscopy; Fibrosis; Follow-Up Studies; Humans; Itraconazole; Lung Diseases, Fungal; Male; Pleura; Pleural Diseases; Remission, Spontaneous; Tomography, X-Ray Computed

Topics: Aged; Amphotericin B; Candidiasis; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis; Peritonitis; Remission, Spontaneous

Spontaneous remission without any anti-cancer therapy in a 57-year-old woman with adult T-cell leukemia (ATL) is reported. The patient was referred to our department because of persistent cough and appearance of abnormal lymphocytes in the peripheral blood, and she was diagnosed as having chronic ATL. Eight months later, she was re-admitted because of cystitis, watery diarrhea and worsening of respiratory symptoms with an increase of ATL cells (WBC 31 x 10(9)/l with 56% ATL cells). Acute exacerbation of ATL was diagnosed. Interestingly, antibiotic therapy for the pulmonary and urinary tract infections brought about spontaneous reduction of the ATL cell count. Spontaneous remission of ATL continued for one year without chemotherapy. The role of infection as a trigger of acute exacerbation and spontaneous remission of ATL is discussed.

Topics: Amphotericin B; Ampicillin; Bone Marrow; Candidiasis; Cystitis; Diarrhea; Escherichia coli Infections; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Leukemia, Prolymphocytic, T-Cell; Middle Aged; Remission, Spontaneous; Respiratory Tract Infections; T-Lymphocytes

Topics: Adolescent; Adult; Aged; Amphotericin B; Candida; Candidiasis; Cross Infection; Endophthalmitis; Female; Humans; Male; Middle Aged; Mycoses; Remission, Spontaneous; Risk; Saccharomyces cerevisiae

Cardiac toxic reactions and pulmonary consolidation in the left lower lobe developed in a patient who was receiving amphotericin B therapy for cryptococcal meningitis. Following surgical resection of the lobe, multiple subcutaneous cryptococcal abscesses appeared. Flucytosine administered intravenously failed to eradicate the lesions. Transfer factor therapy and multiple drainage procedures elimniated the skin abscesses. Transfer factor therapy was administered for one year; the patient was asymptomatic 16 months after therapy was discontinued.

Topics: Abscess; Aged; Amphotericin B; Cryptococcosis; Flucytosine; Heart; Humans; Lung Abscess; Male; Remission, Spontaneous; Skin Diseases, Infectious; Transfer Factor

A 17 year old caucasian woman in whom disseminated coccidioidomycosis developed with culture positive meningitis during her third trimester of pregnancy was treated with amphotericin B and subsequently with transfer factor prepared from her father's peripheral lymphocytes. Clinical response and in vivo and in vitro immunologic data indicated that this transfer factor afforded a significant contribution to her survival whereas previous therapy with transfer factor from an unrelated donor provided only transient immunologic reactivity. This experience suggests that transfer factor prepared from a related donor with positive responses to C. immitis may be more efficacious than that prepared from an unrelated donor.

Topics: Adolescent; Amphotericin B; Coccidioidomycosis; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Parents; Pregnancy; Pregnancy Complications, Infectious; Remission, Spontaneous; Transfer Factor

Topics: Amphotericin B; Child; Coccidioidomycosis; Humans; Male; Remission, Spontaneous

Topics: Amphotericin B; Dose-Response Relationship, Drug; Drug Administration Schedule; Histoplasmosis; Humans; Infusions, Parenteral; Male; Middle Aged; Remission, Spontaneous

Topics: Adolescent; Age Factors; Agranulocytosis; Amphotericin B; Bone Marrow; Child; Child, Preschool; Female; Hepatomegaly; Histoplasmosis; Humans; Leukemia, Lymphoid; Leukopenia; Male; Radiography; Remission, Spontaneous; Splenomegaly

Topics: Amphotericin B; Antigens, Bacterial; Candidiasis, Cutaneous; Child, Preschool; Flucytosine; Humans; Hypersensitivity, Delayed; Immunity, Maternally-Acquired; Immunoglobulin G; Infant; Lectins; Leukocytes; Lymphocytes; Lymphokines; Macrophage Migration-Inhibitory Factors; Male; Peroxidases; Receptors, Drug; Remission, Spontaneous; Time Factors

Topics: Adult; Age Factors; Amphotericin B; Anti-Bacterial Agents; Candidiasis, Cutaneous; Child; Child, Preschool; Chronic Disease; Dermatomycoses; Female; Foot Dermatoses; Furunculosis; Hand Dermatoses; Herpes Zoster; Humans; Immunity, Cellular; Immunity, Maternally-Acquired; Immunotherapy; Infant; Male; Pneumonia; Pyelonephritis; Remission, Spontaneous; Skin Tests; Staphylococcal Infections

Topics: Adolescent; Adult; Amphotericin B; Blastomyces; Blastomycosis; Child; Dosage Forms; Epithelial Cells; Female; Humans; Microbial Sensitivity Tests; Middle Aged; Pregnancy; Remission, Spontaneous; Vagina; Vaginal Diseases; Vaginal Smears

Topics: Aged; Amphotericin B; Aspergillosis; Female; Humans; Lung Diseases, Fungal; Male; Middle Aged; Radiography; Remission, Spontaneous; Sputum; Tuberculosis, Pulmonary

Topics: Adult; Amphotericin B; Aspergillosis; Cytarabine; Female; Humans; Leukemia, Myeloid; Lung Diseases, Fungal; Nystatin; Pulmonary Embolism; Remission, Spontaneous