amphotericin-b and Psoriasis

Fifty patients with a diagnosis of psoriasis, eczematous dermatitis, atopic dermatitis, or neurodermatitis and with bilateral symmetric lesions of equal severity participated in this study. A double-blind paired comparison technique was used in which halcinonide-neomycin-amphotericin ointment was applied to the lesions on one side of the body and hydrocortisone ointment to similar lesions on the other side according to a randomized schedule. The halcinonide-containing combination was statistically superior (p less than 0.05) to hydrocortisone ointment in the treatment of psoriasis patients. No statistically significant difference between the two drugs was obtained for the three other indications studied. No side effects with either ointment were observed. Halcinonide as formulated in this combination is an effective and safe corticosteroid.

Topics: Administration, Topical; Adult; Aged; Amphotericin B; Anti-Inflammatory Agents; Clinical Trials as Topic; Dermatitis; Dermatitis, Atopic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydrocortisone; Infant; Male; Neomycin; Neurodermatitis; Ointments; Pregnenediones; Psoriasis

One hundred patients participated in the studies of cutaneous candidiasis and steroid-responsive dermatoses. Seventy patients with the former diagnosis were treated with either halcinonide-neomycin-amphotericin or hydrocortisone-iodochlorhydroxyquin ointment combinations on a double-blind parallel comparison basis. Similar results were obtained after both therapies. Thirty patients with symmetrical bilateral lesions of steroid-responsive dermatoses were treated with halcinonide-neomycin-amphotericin cream on the lesions on one side of the body and hydrocortisone-iodochlorhydroxyquin cream on the opposite side. A double-blind design was used in directly comparing the response to each of the two drugs. Considering the results of all dermatoses together the test combination was statistically superior to the control cream (p less than 0-05). However, while numerical superiority of good responses to the halcinonide combination was recorded in psoriasis, no statistical significance could be derived due to the limited number of cases. No side-effects occurred with any drug combination use. In the opinion of the authors halcinonide-neomycin-amphotericin cream and ointment are safe and effective in the treatment of cutaneous candiasis and steroid-responsive dermatoses.

Topics: Administration, Topical; Adolescent; Adult; Amphotericin B; Anti-Inflammatory Agents; Candidiasis, Cutaneous; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis; Double-Blind Method; Drug Combinations; Female; Glucocorticoids; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neomycin; Patient Dropouts; Pregnenediones; Psoriasis

Psoriasis is a chronic inflammatory disease that affects over 125 million people worldwide. Many studies have shown the importance of the microbiome for psoriasis exacerbation.. Explore the fungal load and species composition of cultivable yeasts on the skin of psoriatic patients (PP) and healthy volunteers living in a tropical area and evaluate the susceptibility to antifungals.. A cross-sectional study with 61 participants (35 patients and 26 healthy controls) was performed during August 2018 and May 2019. Clinical data were collected from patient interviewing and/or medical records review. Samples were collected by swabbing in up to five anatomic sites. Suggestive yeast colonies were counted and further identified by phenotypical tests, PCR-REA, and/or MALDI-TOF. Susceptibility of Malassezia spp. and Candida spp. to azoles, terbinafine, and amphotericin B was evaluated by broth microdilution.. Nearly 50% of the patients had moderate to severe psoriasis, and plaque-type psoriasis was the most common clinical form. Yeast colonies count was significantly more abundant among PP than healthy controls. Malassezia and Candida were the most abundant genus detected in all participants. Higher MIC values for ketoconazole and terbinafine were observed in Malassezia strains obtained from PP. Approximately 42% of Candida isolates from PP showed resistance to itraconazole in contrast to 12.5% of isolates from healthy controls. MIC values for fluconazole and amphotericin B were significantly different among Candida isolates from PP and healthy individuals.. This study showed that Malassezia and Candida strains from PP presented higher MIC values to widespread antifungal drugs than healthy individuals.

Topics: Amphotericin B; Antifungal Agents; Candida; Cross-Sectional Studies; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Malassezia; Microbial Sensitivity Tests; Psoriasis; Saccharomyces cerevisiae; Terbinafine

This case report highlights the risk of severe cutaneous leishmaniasis (CL) by

Topics: Adrenal Cortex Hormones; Amphotericin B; Antiprotozoal Agents; Humans; Immunocompromised Host; Immunosuppressive Agents; Leishmania infantum; Leishmaniasis, Diffuse Cutaneous; Male; Middle Aged; Psoriasis; Rheumatic Fever; Risk Factors; Spain; Tumor Necrosis Factor-alpha

Topics: Aged; Amphotericin B; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antifungal Agents; Biopsy; Candidiasis; Diagnosis, Differential; Female; Humans; Lichen Planus, Oral; Psoriasis

Low-dose methotrexate sodium therapy used for nonmalignant disease has been associated with a variety of opportunistic infections with pathogens occurring in patients with defective cellular immunity. This article describes the unusual development of disseminated histoplasmosis as a probable complication of immunosuppression resulting from use of methotrexate.. We report the cases of three patients in whom disseminated histoplasmosis developed while receiving low-dose methotrexate therapy for psoriasis. Disease manifestations were unusually severe in two of the three patients. All three cases were disseminated, and two cases resulted in illnesses requiring intensive medical treatment. Each patient responded appropriately to antifungal treatment, although one patient has required long-term suppressive treatment because of persistent Histoplasma antigenuria. These cases illustrate the risk for opportunistic fungal infections in patients receiving low-dose methotrexate therapy for nonmalignant diseases.. Histoplasma should be added to the list of pathogens to be suspected in patients receiving such therapy.

Topics: Acute Disease; Adult; Amphotericin B; Female; Histoplasmosis; Humans; Immunity, Cellular; Male; Methotrexate; Opportunistic Infections; Psoriasis; Time Factors

Topics: Adrenal Cortex Hormones; Amphotericin B; Cryptococcosis; Dermatology; Pathology; Psoriasis; Toxicology