amphotericin-b and Pruritus

Topics: Adult; Amphotericin B; Candidiasis; Candidiasis, Vulvovaginal; Clinical Trials as Topic; Drug Evaluation; Exanthema; Female; Humans; Leukorrhea; Nystatin; Pregnancy; Pruritus

Mucormycosis is a rare opportunistic fungal infection with clinical polymorphism and is rapidly extensive and destructive. It is caused by fungi of the mucorales group in the environment and generally arises in the context of immunosuppression. Often difficult and late, diagnosis is based on mycological and histological examination. We report the case of a 10-year-old patient admitted for a pruritic erythematous scaly eruption located in the right inguinal area associated with satellite lymphadenopathy and lymphedema of the right lower limb. The histological study of the cutaneous biopsy revealed a granulomatous reaction with filaments. The mycological examination of the collection of the cutaneous lesion showed mucorales filaments and a stump of Absidia corymbifera was isolated. Abdomino-pelvic CT showed muscular extension with vascular and ureteral englobement. The diagnosis of cutaneous mucormycosis was made. Immunological investigations were normal. Treatment included itraconazole for 3months followed by IV amphotericin B for 1month, with favorable clinical and radiological progression. Mucormycosis is an uncommon fungal infection whose cutaneous localization is rare. It occurs exceptionally in immunocompetent patients and is clinically manifested by a vesicular and pustular rash progressing to ulceration. The diagnosis is confirmed by mycological and histological studies. Treatment consists of antifungal therapy associated with surgical excision of necrotic and infected tissue.

Topics: Amphotericin B; Antifungal Agents; Child; Dermatomycoses; Erythema; Granuloma; Groin; Humans; Immunocompetence; Itraconazole; Lymphedema; Male; Mucormycosis; Pruritus

Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Cryptococcosis; Diagnosis, Differential; Drug Therapy, Combination; Facial Dermatoses; Female; Flucytosine; HIV Infections; Humans; Pruritus; Radiography

Topics: Adrenal Cortex Hormones; Amphotericin B; Anti-Allergic Agents; Dermatology; Drug Therapy; Histamine H1 Antagonists; Hormones; Humans; Pruritus; Skin Diseases