amphotericin-b and Prostatitis

A 57-year-old Japanese man complained of pain on micturition. The prostate was of normal size but hard. Transrectal needle biopsy demonstrated granulomatous prostatitis with small focal abscesses. Staining with periodic acid-Schiff, Grocott's methenamine silver and Fontana-Masson revealed yeast-form fungus in the granulomas. The mucoid capsule of the fungus stained with mucicarmine. PCR specific for cryptococcal 18S rDNA using DNA extracted from the pathological specimen was positive, and the sequence was homologous to Cryptococcus neoformans. A diagnosis of cryptococcal granulomatous prostatitis was made. The patient was then found to suffer from meningitis and lung abscess, and was treated with amphotericin B and flucytosine. Careful histological and molecular studies are beneficial to reach the correct diagnosis and to prevent an unfavorable outcome of disseminated cryptococcosis.

Topics: Abscess; Amphotericin B; Antifungal Agents; Carmine; Coloring Agents; Cryptococcosis; Cryptococcus neoformans; DNA, Fungal; DNA, Ribosomal; Drug Therapy, Combination; Flucytosine; Granuloma; Humans; Lung Diseases, Fungal; Male; Meningitis, Cryptococcal; Methenamine; Middle Aged; Periodic Acid-Schiff Reaction; Prostatitis; Ribotyping; RNA, Fungal; RNA, Ribosomal, 18S; Silver Nitrate; Staining and Labeling

Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Humans; Kidney Transplantation; Liposomes; Male; Prostatitis

Emphysematous cystitis is characterized by gas collection within the bladder wall and lumen. Often it is the result of aerobic urinary tract infections but it may be caused by gastrointestinal fistulas or iatrogenic surgical and diagnostic instrumentation. We report a case of emphysematous cystitis owing to Candida albicans with the incidental finding of emphysematous changes within the prostate gland.

Topics: Amphotericin B; Candidiasis; Cystitis; Emphysema; Humans; Ketoconazole; Male; Middle Aged; Prostatitis

A 63-year-old man presenting with acute retention and dysuria underwent transurethral resection of the prostate for suspected benign prostatic hypertrophy. Ten days postoperatively he developed disseminated cryptococcosis. Re-examination of the prostatic chips revealed cryptococcal prostatitis. Treatment consisted of amphotericin, flucytosine and transfer factor along with wedge resection of a pulmonary toruloma. He remains well 12 months after cessation of treatment. This appears to be the first case report in Australia of cryptococcal prostatitis with dissemination after transurethral resection of the prostate.

Topics: Amphotericin B; Cryptococcosis; Flucytosine; Humans; Lung Diseases, Fungal; Male; Middle Aged; Prostatectomy; Prostatitis; Transfer Factor; Urethra

A case of granulomatous prostatitis due to Cryptococcus neoformans is reported. The patient, who had a history of diabetes mellitus and chronic active hepatitis, had symptoms of prostatic hypertrophy. Tissue obtained from surgery showed granulomatous prostatitis, and a cryptococcal organism was identified by special stains. Postoperative cultures grew Cryptococcus neoformans, and the patient was treated successfully with surgery and a short course of amphotericin B. After nine months of follow-up, there is no evidence of systemic infection.

Topics: Amphotericin B; Cryptococcosis; Cryptococcus neoformans; Diabetes Complications; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Prostatectomy; Prostatitis

Topics: Amphotericin B; Candida; Candidiasis; Humans; Male; Prostatitis; Urethritis

Topics: Amphotericin B; Candida albicans; Candidiasis; Cystitis; Female; Flucytosine; Humans; Kidney Diseases; Male; Prostatitis; Urinary Catheterization; Urinary Tract Infections

Topics: Adult; Amphotericin B; Coccidioidomycosis; Epididymitis; Humans; Male; Prostatitis

Topics: Amphotericin B; Antineoplastic Agents; Cryptococcosis; Drug Therapy; Hodgkin Disease; Humans; Male; Pathology; Prostatitis