amphotericin-b and Prostatic-Diseases

Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Central Nervous System Diseases; Cryptococcosis; Eye Infections, Fungal; Fluconazole; Humans; Lung Diseases, Fungal; Male; Prostatic Diseases

Symptomatic involvement of the genitourinary tract as a manifestation of disseminated Coccidioides immitis infection is uncommon. We report a case of a colovesical fistula secondary to Coccidioides immitis infection and review the pertinent medical literature.

Topics: Adult; Amphotericin B; Coccidioidomycosis; Genital Diseases, Male; Humans; Hydronephrosis; Intestinal Fistula; Ketoconazole; Male; Prostatic Diseases; Sigmoid Diseases; Urinary Bladder Diseases; Urinary Bladder Fistula

Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Confidence Intervals; Cryptococcosis; Fluconazole; Humans; Male; Meningitis; Prospective Studies; Prostatic Diseases; Recurrence

To assess the frequency of persistent Cryptococcus neoformans infection in patients with the acquired immunodeficiency syndrome (AIDS) after receiving apparently adequate treatment for meningitis.. Blood, urine, and cerebrospinal fluid were cultured at the conclusion of primary therapy to assess the adequacy of treatment.. Outpatient clinics at three medical centers.. Patients had C. neoformans grown in culture from cerebrospinal fluid. Primary therapy consisted of either 2.0 g of amphotericin B alone; 6 weeks of combination therapy with flucytosine; or, if flucytosine was poorly tolerated, an adjusted minimum total amphotericin B dose. To meet criteria for adequate treatment of meningitis all patients had two sequential cerebrospinal fluid samples which were culture negative.. Nine of forty-one patients grew C. neoformans from urine after completion of primary treatment, but none had urinary symptoms. Fungi were visualized in expressed prostatic secretions in 4 of these patients. One patient refused further treatment and developed cryptococcemia within 5 weeks. Three patients received additional amphotericin B; all had persistent funguria without systemic relapse. Six patients received fluconazole; 4 became urine culture negative, and 2 had systemic relapse.. The persistence of urinary C. neoformans after adequate therapy for meningitis suggests that the urinary tract (probably the prostate) is a sequestered reservoir of infection from which systemic relapse may occur.

Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Drug Therapy, Combination; Fluconazole; Humans; Male; Meningitis; Prostatic Diseases; Recurrence; Triazoles; Urine

Topics: Aged; Amphotericin B; Coccidioidomycosis; Diagnosis, Differential; Humans; Male; Prostatic Diseases; Prostatic Hyperplasia

A case of disseminated coccidioidomycosis was diagnosed from a prostatic biopsy. Patients with sterile pyuria, prostatic nodules or symptoms of prostatitis who have lived in or traveled through an endemic area need careful evaluation of the lower genitourinary tract. Immunological treatment with a transfer factor currently is under investigation. Miconazole may offer a promise for future treatment of this fungal infection and, particularly, for patients with impaired renal function.

Topics: Amphotericin B; Biopsy; Coccidioidomycosis; Humans; Immunotherapy; Male; Miconazole; Middle Aged; Prostatic Diseases; Transfer Factor

In a retrospective study of 51 cases of systemic North American blastomycosis 11 patients were found to have genitourinary tract involvement, the prostate and epididymis being most commonly affected. Diagnosis was made by culture of the fungus from urine, abscess or prostate secretions, morphologic identification of the characteristic organism in urine or secretions, or histologic examination of tissue specimens. Treatment with amphotericin B reduced the mortality rate of 90 per cent to as low as 10 per cent. Long-term followup is necessary because of a relapse rate of 10 to 15 per cent.

Topics: Adult; Aged; Amphotericin B; Blastomycosis; Epididymitis; Genital Diseases, Male; Humans; Kidney Diseases; Male; Middle Aged; Penile Diseases; Potassium Iodide; Prostatic Diseases; Stilbamidines; Testicular Diseases

Topics: Amphotericin B; Biopsy; Histoplasma; Histoplasmosis; Humans; Male; Middle Aged; Prostatic Diseases; Radiography; Seminal Vesicles; Skin Diseases; Skin Manifestations

Topics: Aminosalicylic Acids; Amphotericin B; Blastomycosis; Coitus; Endometritis; Epididymis; Fallopian Tubes; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Isoniazid; Lung; Male; Middle Aged; Peritoneal Diseases; Prostatic Diseases; Radiography; Sexually Transmitted Diseases; Testicular Diseases; Urogenital System; Urologic Diseases; Uterine Diseases

Topics: Abscess; Adolescent; Amphotericin B; Blastomyces; Blastomycosis; Bone Diseases; Foot Diseases; Humans; Leprosy; Lung Diseases; Male; Mozambique; Prostatic Diseases; Skin Diseases; Sputum

Topics: Adolescent; Amphotericin B; Cryptococcosis; Hematuria; Humans; Male; Prostatic Diseases; Pyuria; Urination Disorders