amphotericin-b and Pharyngitis

The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma autoantibodies. T. marneffei usually causes invasive and disseminated infections, including fungemia. T. marneffei oro-pharyngo-laryngitis is an unusual manifestation of talaromycosis.. A 52-year-old Thai woman had been diagnosed anti-IFNɣ autoantibodies for 4 years. She had a sore throat, odynophagia, and hoarseness for 3 weeks. She also had febrile symptoms and lost 5 kg in weight. Physical examination revealed marked swelling and hyperemia of both sides of the tonsils, the uvula and palatal arches including a swelling of the epiglottis, and arytenoid. The right tonsillar biopsy exhibited a few intracellular oval and elongated yeast-like organisms with some central transverse septum seen, which subsequently grew a few colonies of T. marneffei on fungal cultures. The patient received amphotericin B deoxycholate 45 mg/dayfor 1 weeks, followed by oral itraconazole 400 mg/day for several months. Her symptoms completely resolved without complication.. In patients with anti-IFN-ɣ autoantibodies, T. marneffei can rarely cause a local infection involving oropharynx and larynx. Fungal culture and pathological examination are warranted for diagnosis T. marneffei oro-pharyngo-laryngitis. This condition requires a long term antifungal therapy.

Topics: Amphotericin B; Antifungal Agents; Autoantibodies; Deoxycholic Acid; Drug Combinations; Female; Humans; Interferon-gamma; Itraconazole; Laryngitis; Middle Aged; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Mycoses; Pharyngitis; Talaromyces; Thailand

Topics: Adolescent; Amphotericin B; Antifungal Agents; Coccidioidomycosis; Fluconazole; Follow-Up Studies; Humans; Male; Pharyngitis; Retropharyngeal Abscess

Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Candida albicans; Candidiasis; Candidiasis, Oral; Drug Administration Schedule; Drug Resistance, Microbial; Fluconazole; Humans; Pharyngitis; Treatment Failure

Topics: Amphotericin B; Ampicillin; Brain Abscess; Candidiasis; Cryptococcosis; Enterobacteriaceae Infections; Esophagitis; Herpes Simplex; Humans; Infections; Meningitis; Meningitis, Listeria; Mucormycosis; Neoplasms; Pharyngitis; Stomatitis; Toxoplasmosis

Topics: Amphotericin B; Ampicillin; Anti-Bacterial Agents; Aspirin; Cephalexin; Drug Prescriptions; Erythromycin; Haemophilus influenzae; Humans; Metronidazole; Nystatin; Otitis Media; Penicillins; Pharyngitis; Staphylococcus; Streptococcus pyogenes

Topics: Amphotericin B; Chronic Disease; Humans; Natamycin; Nystatin; Pharyngitis