amphotericin-b and Pelvic-Pain

A 44-year-old man is presented here with 14 years of chronic purulent sinusitis, a chronic fungal rash of the scrotum, and chronic pelvic pain. Treatment with antifungal therapy resulted in symptom improvement, however he was unable to establish an effective long-term treatment regimen, resulting in debilitating symptoms. He had undergone extensive work-up without identifying a clear underlying etiology, although Candida species were cultured from the prostatic fluid. 100 genes involved in the cellular immune response were sequenced and a missense mutation was identified in the Ras-binding domain of PI3Kγ. PI3Kγ is a crucial signaling element in leukotaxis and other leukocyte functions. We hypothesize that his mutation led to his chronic infections and pelvic pain.

Topics: Adult; Amphotericin B; Antifungal Agents; Base Sequence; Chronic Disease; Class Ib Phosphatidylinositol 3-Kinase; DNA Mutational Analysis; Exome; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoglobulins, Intravenous; Leukocyte Count; Male; Molecular Sequence Data; Mutation; Pelvic Pain; Reproducibility of Results