amphotericin-b and Neonatal-Sepsis

Compare the oral colonization profile of premature infants admitted at NICU before and after doing oral care routine with sterile water versus no intervention.. It was a randomized clinical trial composed of 37 premature infants admitted at the Neonatal Intensive Care Unit (NICU) with a birth weight (BW) <1500 g. They were distributed in two groups: the study group (SG) with 15 patients who received an oral hygiene with sterile water; and a control group (CG) (no intervention) formed by 22 patients. Primary outcome was oral colonization profile before and after doing oral care.. In the study group, the number of patients colonized by the Gram-positive bacteria at the beginning of the study was 53% versus 40% at the end (p=0.10). For Gram negative, 40% at the study's beginning versus 60% at the end (p=0.18). In the control group, the number of colonized patients for the Gram-positive bacteria at the onset of the study was 54.5% versus 32% patients at the end (p=0.24). For Gram negative, 32% patients at the start of the study versus 77% at the end (p = 0.003).. There is a significant increase of the Gram-negative flora in those patients without oral care.

Topics: Amphotericin B; Anti-Bacterial Agents; Birth Weight; Chemoprevention; Cross Infection; Female; Fluconazole; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Mouth; Neonatal Sepsis; Oral Hygiene

With improved and prolonged survival of very and extremely low birth weight infants, invasive fungal infection has emerged as an important concern in the neonatal intensive care units. Candidiasis is the third leading cause of late onset sepsis in these neonates and is associated with 20-30% mortality. Extreme prematurity, central venous catheters, prolonged antibiotic exposure, parenteral nutrition are important risk factors. Various forms of cutaneous manifestations of candidiasis have been described ranging from local diaper dermatitis and oral thrush to widespread erosive and ulcerative lesions with extensive crusting in invasive fungal dermatitis. We report a series of four cases with cutaneous hyperpigmentation as manifestation of systemic candidiasis.

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candidemia; Candidiasis, Invasive; Female; Humans; Hyperpigmentation; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Neonatal Sepsis