amphotericin-b and Multifocal-Choroiditis

A rare case of 70-year-old woman with adult T-cell leukemia/lymphoma who developed multifocal choroiditis from a dissemination of Cryptococcus neoformans is reported. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes. Sequential optical coherence tomographic images disclosed the involvement of the choroid and the consecutive changes in its architecture during the course of treatment. The recognition of these ocular manifestations may be important for the rapid diagnosis of C. nerformans-disseminated diseases. Rapid diagnosis and prompt therapy with intravitreal injection as well as systemic fosfluconazole and liposomal amphotericin B led to clinical improvement of intraocular cryptococcosis.

Topics: Aged; Amphotericin B; Antifungal Agents; Choroiditis; Cryptococcosis; Cryptococcus neoformans; Eye; Eye Infections, Fungal; Fatal Outcome; Female; Fluconazole; Humans; Intravitreal Injections; Leukemia-Lymphoma, Adult T-Cell; Multifocal Choroiditis; Organophosphates; Tomography, Optical Coherence