amphotericin-b and Meningeal-Neoplasms

Topics: Amphotericin B; Anti-Inflammatory Agents; Antifungal Agents; Aspergillosis; Diabetes Complications; Humans; Immunocompromised Host; Lung Diseases, Fungal; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neurosurgical Procedures; Pneumonectomy; Steroids

We describe a case of post-operative ventriculitis in an immunocompetent patient caused by an unusual organism, namely Rhodotorula rubra. The patient was treated successfully with antifungal agents.

Topics: Adult; Amphotericin B; Cerebral Ventricles; Encephalitis; Female; Flucytosine; Humans; Immune Tolerance; Meningeal Neoplasms; Meningioma; Mycoses; Postoperative Complications; Rhodotorula

A favourable outcome was observed in a 12 year-old boy who developed invasive pulmonary and cerebral aspergillosis during antineoplastic treatment for central nervous system relapse of acute lymphoblastic leukemia. Combination therapy with amphotericin B and 5-Fluorocytosine led to complete regression of pulmonary infiltrates. Despite enlargement of the cerebral lesion monitored by computerized tomography, no viable fungi were found in the completely resected abscess after a 4 weeks' course of antifungal treatment preceding neurosurgery. Histological examination confirmed the diagnosis of an aspergillotic abscess. The initially severe neurological symptoms disappeared after successful surgery. Aspergillus fumigatus was detected in the soil of a potted ornamental plant in the mother's living room, suggesting that this might have been the source of the infectious agent.

Topics: Amphotericin B; Aspergillosis; Aspergillus fumigatus; Brain Abscess; Child; Flucytosine; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Lung Diseases, Fungal; Male; Meningeal Neoplasms