amphotericin-b and Melanoma

Signo del cornete negro en un caso de mucormicosis rinocerebral.

Topics: Aged; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cavernous Sinus Thrombosis; Combined Modality Therapy; Cranial Nerve Diseases; Dexamethasone; Diagnosis, Differential; Disease Progression; Encephalitis; Ethmoid Sinusitis; Fatal Outcome; Humans; Interferons; Magnetic Resonance Imaging; Male; Maxillary Sinusitis; Melanoma; Mucormycosis; Opportunistic Infections; Rhizopus; Spinal Neoplasms; Tomography, X-Ray Computed; Turbinates

Topics: Amphotericin B; Animals; Cell Line; Dacarbazine; Drug Interactions; Humans; Leukemia, Experimental; Melanoma; Mice; Mycosis Fungoides; Neoplasms, Experimental

B16 melanoma-bearing mice had a reduced capacity to mount a delayed-type hypersensitivity response, and this response was further depressed when these mice were also treated with multiple daily doses of amphotericin B (AmB). Results from the present experiments, which were designed to simulate the clinical situation, indicate that patients receiving AmB may require frequent monitoring of immune functions during treatment.

Topics: Amphotericin B; Animals; Antibodies; Cells, Cultured; Hypersensitivity, Delayed; Immunosuppression Therapy; Melanoma; Mice; Mice, Inbred C57BL; Mycoses; Neoplasms, Experimental

Satisfactory chemotherapeutic management of malignant melanomas in advanced stages must await development of more active agents and combinations of them than are presently available. The development of entirely new means of treatment by hormones, heat, and adjuvants like amphotericin B may improve the efficacy of currently available agents.

Topics: Amphotericin B; BCG Vaccine; Dacarbazine; Drug Combinations; Estradiol Congeners; Female; Hot Temperature; Humans; Melanoma; Methotrexate; Neoplasm Metastasis; Nitrosourea Compounds; Skin Neoplasms