amphotericin-b and Mastoiditis

Rhino-sinusal infections are serious diseases and possibly lethal. When they are invasive, we easily discuss apergilloses and mucormycoses. The confirmation of the diagnosis of mucormycosis need an extensive surgery for precise histopathological and mycological evaluation. The pathologist may be faced to other rare mycoses such as phaeohyphomycoses, which present different morphological features than mucormycoses and Aspergillus. Once the diagnosis is established, an appropriate antifungal treatment is quickly started. The aim of our work is to report two observations of phaeohyphomycoses, to describe their histopathological features, to discuss complementary diagnostic methods and to present the main differential diagnoses.

Topics: Adult; Alternaria; Alternariosis; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Debridement; Diagnosis, Differential; Early Diagnosis; Fatal Outcome; Female; Humans; Liposomes; Mastoiditis; Phaeohyphomycosis; Postoperative Complications; Retrospective Studies; Rhinitis; Shock, Septic; Sinusitis

Herein, we report a case of otitis externa caused by Malassezia slooffiae complicated with mastoiditis. A 70-year-old male complained of fever and severe otorrhea from left external auditory canal 2 months after undergoing a craniotomy to remove a hematoma. He had right-sided paralysis and undertook bed rest. Brain computed tomography revealed continuous fluid accumulation in the left mastoid air cells and middle ear from left external auditory canal in addition to leukocytosis and increased C-reactive protein level. The tympanic membrane was severely swelling. These results indicated the presence of otitis media and mastoiditis. Otorrhea culture showed large amounts of M. slooffiae. The administration of liposomal amphotericin B (L-AMB), the irrigation of external auditory canal with normal saline, and the application of topical ketoconazole ointment were started. The administration of L-AMB for 8 weeks and voriconazole, which was switched from L-AMB, for 4 weeks ameliorated his infection and he was transferred to another hospital to receive rehabilitation. From these results and his clinical course, the diagnosis of otitis externa caused by Malassezia slooffiae complicated with mastoiditis was made. And the possibility of the contamination by M. slooffiae was very low. Clinicians should be aware that M.slooffiae can provoke otological infections since M. slooffiae is the most common Malassezia sp. in external auditory canal.

Topics: Aged; Dermatomycoses; Humans; Malassezia; Male; Mastoiditis; Otitis Externa

To report an unusual case of fungal mastoiditis caused by entomophthorales in an immunocompetent patient, and its management.. Case report with a review of the literature.. A 13-year-old girl presented to us with a mastoid abscess. Entomophthoromycotic infection of the mastoid was diagnosed on histopathological examination, and subsequently treated with surgical debridement and amphotericin B injection.. This is the first reported case of mastoid abscess secondary to entomophthoromycosis. Early detection and treatment contributed to this patient's good outcome.

Topics: Abscess; Adolescent; Amphotericin B; Antifungal Agents; Audiometry, Pure-Tone; Debridement; Ear Canal; Entomophthorales; Female; Hearing Loss, Conductive; Humans; Mastoiditis; Temporal Bone; Tomography, X-Ray Computed; Zygomycosis

Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Fatal Outcome; Humans; Male; Mastoiditis; Otitis Media with Effusion

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Female; Humans; Ketoconazole; Mastoiditis; Middle Aged; Temporal Bone; Tomography, X-Ray Computed; Tympanic Membrane

Topics: Adult; Aged; Amphotericin B; Aspergillosis; Aspergillus fumigatus; Female; Humans; Male; Mastoiditis

Topics: Adult; Amphotericin B; Eye Manifestations; Eyelids; Humans; Injections, Intravenous; Male; Mastoiditis; Middle Aged; Mucor; Mucormycosis; Otitis Media; Rhinitis; Skin Manifestations