amphotericin-b and Mandibular-Diseases

Mucormycosis (phycomycosis, zygomycosis) is an acute opportunistic infection caused by a saprophytic fungus found in soil, bread molds, and decaying fruits and vegetables. Numerous predisposing risk factors are associated with mucormycosis, although most cases have been reported in poorly controlled diabetics or in patients with hematologic malignant conditions. This report presents two cases of oral mucormycosis. One case occurred in the maxilla in a patient with well-controlled diabetes. The other involved the mandible and overlying gingiva in a patient with acute myelogenous leukemia. A review of the literature concerning oral mucormycosis is also presented.

Topics: Adult; Aged; Amphotericin B; Candidiasis, Oral; Diabetes Complications; Gingival Diseases; Humans; Leukemia, Myeloid, Acute; Male; Mandibular Diseases; Maxillary Diseases; Mouth Diseases; Mucormycosis

Invasive aspergillosis in healthy hosts is a very rare occurrence, but it may become pathogenic under certain circumstances. In the head and neck region, aspergillosis usually involves the maxillary sinus. This case report describes secondary Aspergillus infection of the mandible in a 35-year-old female patient in whom the maxillary sinus was primarily involved 5 years previously.

Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Female; Fluconazole; Humans; Mandibular Diseases; Maxillary Sinusitis; Recurrence; Tooth Extraction

Coccidioidomycotic osteomyelitis developed at the angle of the right side of the mandible in a 5-month-old Papago infant. The disease was successfully treated with a combination of amphotericin B, surgery, and transfer factor with complete immunological, microbiological, and radiological cure. At 4 years of age, the only residual effect is prominence of the right hemimandible with asymmetry of the jaw.

Topics: Amphotericin B; Child, Preschool; Coccidioides; Coccidioidomycosis; Female; Humans; Infant; Mandibular Diseases; Osteomyelitis; Radiography