amphotericin-b and Liver-Cirrhosis--Alcoholic

Saccharomyces cerevisiae is usually considered non-pathogenic and has rarely been reported as a cause of fungemia in immunocompromised patients, especially those admitted to an intensive care unit or those affected by acquired immune deficiency syndrome or under immunosuppressive treatment. In all described cases the use of probiotic yeast has been given as the main risk factor. We report a case of S. cerevisiae sepsis complicated by pneumonia in a patient affected by alcohol-related cirrhosis with no evidence of probiotic drug intake. In this case recovery was obtained after a treatment course with liposomal amphotericin B. S. cerevisiae should be taken into consideration when sepsis lacks to isolate any aetiological agent.

Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Fluconazole; Humans; Immunocompromised Host; Itraconazole; Liver Cirrhosis, Alcoholic; Lung Diseases, Fungal; Male; Middle Aged; Pyrimidines; Radiography; Saccharomyces cerevisiae; Treatment Outcome; Triazoles; Voriconazole

Gastric zygomycosis is a rare but potentially lethal complication in transplant patients. Forty-two cases of gastric mucormycosis have been described in the literature, with a mortality of 98%.. We report of a case of gastric mucormycosis in a 45-year-old male undergoing liver transplantation for alcohol-induced cirrhosis. The diagnosis was made 20 days after transplantation in a biopsy of a bleeding gastric ulcer identified during a reoperation for a common bile duct stricture.. After the surgical procedure and therapy with amphotericin B, the patient made a good recovery and is alive and well 2 years after transplantation.. Gastric mucormycosis should be suspected in those patients in whom gastrointestinal symptoms such a pain or bleeding are present. Because the diagnosis is dependent on histology, the importance of biopsy cannot be underestimated. Once diagnosed, a successful outcome depends on effective treatment with amphotericin.

Topics: Amphotericin B; Antifungal Agents; Biopsy; Follow-Up Studies; Gastrointestinal Diseases; Humans; Liver Cirrhosis, Alcoholic; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Reoperation; Stomach Ulcer; Time Factors; Treatment Outcome; Zygomycosis

Topics: Adult; Amphotericin B; Antifungal Agents; Debridement; Drug Therapy, Combination; Hepatitis C; Humans; Immunosuppressive Agents; Liver Cirrhosis, Alcoholic; Liver Transplantation; Male; Mucormycosis; Opportunistic Infections; Postoperative Complications

A 47-year-old man with cirrhosis developed a case of previously unreported olecranon bursitis due to Cryptococcus neoformans. Most patients with disseminated cryptococcosis have deficiencies in cell mediated immunity. Cirrhosis may be an independent risk factor because of impaired chemotaxis and phagocytosis.

Topics: Amphotericin B; Bursitis; Cryptococcosis; Elbow; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged

Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Aspergillosis; Dermatomycoses; Graft Rejection; Humans; Immunosuppressive Agents; Liver Cirrhosis, Alcoholic; Liver Transplantation; Lung Diseases; Male; Middle Aged