amphotericin-b and Kidney-Calculi

Primary renal aspergillosis is rare in diabetic patients. Diagnosis of localized primary renal Aspergillus infection in diabetic patients requires careful investigations due to its benign presentation and lack of associated systemic clinical features. There is also paucity of information on the role of conservative treatment of such localized infection with antifungal agents only. Here, we describe a case of localized renal aspergillosis in a type 2 diabetic patient with a brief review of literature.. We describe a case of unilateral renal aspergillosis following intracorporeal pneumatic lithotripsy (ICPL) in a type 2 diabetic man. The patient presented with mild pain in the left lumbar region and periodic expulsion of whitish soft masses per urethra, which yielded growth of Aspergillus fumigatus. He was treated initially with amphotericin B; however, it was stopped after 2 weeks, as he could not tolerate the drug. Subsequently, he was successfully treated with oral itraconazole.. Localized renal aspergillosis may be suspected in diabetic patients having history of urinary tract instrumentation, mild lumbar pain, passage of suspicious masses in urine and persistent pyuria. Examination of the suspicious substances expelled per urethra is essential for diagnosis as routine multiple urine analysis may yield negative results. Conservative treatment with oral itraconazole alone is effective in cases with incomplete obstruction.

Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Diabetes Complications; Humans; Itraconazole; Kidney Calculi; Lithotripsy; Male; Middle Aged; Stents; Urinary Tract Infections

Two very low birth weight infants who developed renal candidiasis with pelvicalyceal fungal concretions were treated medically with Amphotericin B and 5 Fluorocytosine. Two months following cessation of therapy, the fungal concretions decreased in size, became sterile and developed calcification in residual debris. The calcifications was still present at demise in one patient and at 18 months follow up in the other. These calcifications occurred in the absence of simultaneous furosemide therapy.

Topics: Amphotericin B; Candidiasis; Female; Flucytosine; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Kidney Calculi; Kidney Diseases

We have presented a case of a stable diabetic outpatient who had an acute illness that proved to be Torulopsis glabrata fungemia responsive to amphotericin B therapy. Her only apparent additional predisposition was a nonobstructing renal calculus. Fungemia with this organism in an outpatient is most unusual. T glabrata should be an additional consideration in outpatient as well as inpatient illnesses, especially in diabetic women.

Topics: Amphotericin B; Candidiasis; Diabetes Mellitus, Type 2; Female; Humans; Kidney Calculi; Middle Aged; Opportunistic Infections

Topics: Acidosis; Adolescent; Amphotericin B; Brain Diseases; Female; Humans; Kidney Calculi; Mucormycosis; Nose Diseases

Topics: Adult; Amphotericin B; Candidiasis; Female; Flucytosine; Humans; Kidney; Kidney Calculi; Pyelonephritis; Urine

Topics: Amphotericin B; Blood; Blood Chemical Analysis; Blood Urea Nitrogen; Creatine; Creatinine; Cryptococcosis; Drug Therapy; Hematocrit; Histoplasmosis; Kidney Calculi; Kidney Diseases; Pathology; Phenolphthaleins; Potassium; Sodium; Sodium, Dietary; Toxicology; Urea; Urine