amphotericin-b and Iritis

Intraocular infection due to Blastomyces dermatitidis is rare, and only 10 cases have previously been reported. Manifestations of ocular blastomycosis can range from keratitis to panophthalmitis, and it is often difficult to diagnose ocular blastomycosis early. We report the case of a 45-year-old man who had disseminated blastomycosis that involved the lungs, skin, and ocular uvea and who was successfully treated with systemic and local antifungal therapy. We also review the literature describing the spectrum of clinical findings due to intraocular blastomycosis.

Topics: Amphotericin B; Betamethasone; Blastomycosis; Dermatomycoses; Drug Therapy, Combination; Humans; Iritis; Lung Diseases, Fungal; Male; Miconazole; Middle Aged

We studied, in a rabbit, the ocular toxicity of topical 1% solutions or suspensions of amphotericin B, flucytosine, miconazole nitrate, and ketoconazole. Flucytosine, miconazole, and ketoconazole did not retard the closure of 8.5-mm corneal epithelial defects; amphotericin B greatly retarded the closure of such defects. Amphotericin B produced dramatic pathologic changes in this model; these changes worsened with each day of therapy. Ketoconazole produced modest biomicroscopically and histologically detectable pathologic changes in the regenerating corneal epithelium; flucytosine and miconazole did not produce such changes.

Topics: Administration, Topical; Amphotericin B; Animals; Antifungal Agents; Cornea; Eye; Flucytosine; Imidazoles; Iritis; Ketoconazole; Miconazole; Piperazines; Rabbits

Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Candida; Candidiasis; Conjunctivitis; Cytosine; Endophthalmitis; Female; Fluorine; Humans; Infant, Newborn; Infant, Premature; Iritis; Male; Middle Aged

Topics: Amphotericin B; Animals; Aspergillosis; Candidiasis; Cornea; Iritis; Keratitis; Natamycin; Nystatin; Potassium; Potassium Iodide; Rabbits; Sodium

Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus; Benzalkonium Compounds; Candida; Copper; Corneal Ulcer; Dexamethasone; Drug Synergism; Injections; Iritis; Keratitis; Mycoses; Nystatin; Ophthalmic Solutions; Potassium Iodide; Pyridines; Rabbits; Sulfates

Topics: Amphotericin B; Animals; Ciliary Body; Eye Diseases; Histoplasmosis; Hyperemia; In Vitro Techniques; Iritis; Necrosis; Rabbits