amphotericin-b and Hypertension--Pulmonary

A 28 year old man with asthma, bronchopulmonary aspergillosis, pulmonary thromboembolic disease, and pulmonary hypertension developed Aspergillus fumigatus empyema complicating a pneumothorax. His condition progressively deteriorated despite treatment with intravenous and intrapleural amphotericin B, but improved promptly after substituting nebulised liposomal amphotericin B and oral itraconazole. This experience suggests that nebulised liposomal amphotericin B is well tolerated and merits further assessment in the treatment of pulmonary fungal disease.

Topics: Administration, Inhalation; Administration, Oral; Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Asthma; Drug Carriers; Drug Therapy, Combination; Empyema, Pleural; Humans; Hypertension, Pulmonary; Itraconazole; Liposomes; Male; Nebulizers and Vaporizers; Pulmonary Embolism