amphotericin-b and Hyperplasia

The role of fungi in chronic rhinosinusitis (CRS) is not clear. Fungi can be detected in the nose and paranasal sinuses of virtually all CRS patients; however, they also appear to be present in healthy controls. Various theories attempt to explain the mechanisms by which fungi can exert an effect on sinus mucosa in susceptible individuals. Further studies are necessary to clarify the role of fungi in CRS, which fungal organisms (if any) are pathogenic, and what exactly characterizes the immunologic response to fungi that may result in the development of disease. However, in the absence of convincing immunologic data and evidence of clinical improvement of CRS after antifungal therapy, the case against the fungus remains unproven.

Topics: Amphotericin B; Antifungal Agents; Antimicrobial Cationic Peptides; Chronic Disease; Cytokines; Fungi; Humans; Hyperplasia; Hypersensitivity; Immunotherapy; Mycoses; Pulmonary Surfactant-Associated Protein D; Sinusitis

Laryngeal candidiasis is very rare in the absence of other more proximal diseases in the aerodigestive tract. The lesion shows pseudoepitheliomatous hyperplasia or acanthosis and, given its rarity, may be confused with cancer. In the present paper we report on a 56-year-old male patient who presented with hoarseness. Physical examination of the larynx revealed a hyperplastic lesion involving both vocal cords. The clinical aspect and the risk factor profile of the patient (ten bottles of beer and 40 cigarettes per day) generated the clinical diagnosis of laryngeal cancer. A biopsy was taken. The histopathological examination of the specimen excluded a squamous cell carcinoma; however, it could not provide a clear diagnosis. Laryngeal papillomatosis and tuberculosis, which had been suspected, could be excluded. As the lesion progressed, further biopsies led to the diagnosis of candidiasis. Systemic antimycotic treatment with fluconazol and amphotericin caused a complete remission.

Topics: Amphotericin B; Antifungal Agents; Biopsy; Candidiasis; Diagnosis, Differential; Fluconazole; Follow-Up Studies; Humans; Hyperplasia; Laryngeal Diseases; Laryngeal Neoplasms; Laryngoscopy; Male; Middle Aged; Papilloma; Vocal Cords

Topics: Adult; Aged; Amphotericin B; Candidiasis, Oral; Carcinoma, Squamous Cell; Chronic Disease; Humans; Hyperplasia; Male; Middle Aged; Mouth Neoplasms; Precancerous Conditions