amphotericin-b and Hyperpigmentation

With improved and prolonged survival of very and extremely low birth weight infants, invasive fungal infection has emerged as an important concern in the neonatal intensive care units. Candidiasis is the third leading cause of late onset sepsis in these neonates and is associated with 20-30% mortality. Extreme prematurity, central venous catheters, prolonged antibiotic exposure, parenteral nutrition are important risk factors. Various forms of cutaneous manifestations of candidiasis have been described ranging from local diaper dermatitis and oral thrush to widespread erosive and ulcerative lesions with extensive crusting in invasive fungal dermatitis. We report a series of four cases with cutaneous hyperpigmentation as manifestation of systemic candidiasis.

Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candidemia; Candidiasis, Invasive; Female; Humans; Hyperpigmentation; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Neonatal Sepsis

Topics: Amphotericin B; Bone Marrow Examination; Child; Diagnosis, Differential; Female; Hepatomegaly; Humans; Hyperpigmentation; Leishmania; Leishmaniasis; Neglected Diseases; Splenomegaly