amphotericin-b and Hypergammaglobulinemia

Clinicians have usually considered malignancies during follow up of patients who have infectious diseases as a pre-diagnosis. However, malignancy and an infectious disease are seen together more rarely, with the exception of immunosuppressed patients. This presentation is a case report followed up for fever of unknown origin. The patient was admitted to the hospital with the symptoms of fever, weight loss, abdominal pain and weakness. Anemia and hypergamaglobulinemia by biochemical analyses and splenomegaly by total body computed tomography were detected. Amastigotes were seen in bone marrow aspiration smears and promastigotes were isolated in NNN medium. At the end of the Liposomal Amphotericin B treatment, control bone marrow aspiration was applied. Leishmania amastigotes were not seen, while patient was diagnosed as diffuse B cell lymphoma pathologically.

Topics: Abdominal Pain; Amphotericin B; Anemia; Anticestodal Agents; Bone Marrow; Female; Fever of Unknown Origin; Humans; Hypergammaglobulinemia; Leishmania; Leishmaniasis, Visceral; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Splenomegaly; Tomography, X-Ray Computed; Weight Loss

Coexistence of two illnesses in the same patient may result in atypical manifestations of either or both diseases. A case of hepatitis B virus-related cirrhosis in a patient who presented with a pharyngeal mucosal mass lesion as a manifestation of superadded Leishmania infection is presented here. The clue to the diagnosis was the origin of the patient from an area highly endemic for leishmaniasis and the presence of unexplained polyclonal hypergammaglobulinaemia. The patient responded very well to therapy with amphotericin B with complete disappearance of the mucosal lesion.

Topics: Adult; Amphotericin B; Endemic Diseases; Hepatitis B, Chronic; Humans; Hypergammaglobulinemia; Leishmaniasis; Liver Cirrhosis; Male; Mucous Membrane; Pharynx

A case is reported of cryptococcal meningitis in a 27-y-old male suffering from X-linked hyper-IgM1 syndrome. This congenital disorder is characterized by multiple infections of the respiratory and gastrointestinal tracts, but also opportunistic infections commonly seen in patients with cell-mediated immunity. His clinical recovery was good but the need for life-long secondary chemoprophylaxis to prevent relapses is unknown.

Topics: Adult; Amphotericin B; Antifungal Agents; Deoxycholic Acid; Drug Combinations; Fluconazole; Genetic Diseases, X-Linked; Humans; Hypergammaglobulinemia; Immunoglobulin M; Male; Meningitis, Cryptococcal

Invasive fungal infections of the hand are extremely rare and usually require an immunocompromised host. We report the first known case of Candida albicans tenosynovitis of the hand presenting as a mass in a boy with Buckley's immunodeficiency. Treatment was successful after radical synovectomy of both the flexor and extensor aspects of the hand after he failed to respond to combined amphotericin B and 5-fluorouracil therapy. Fungal tenosynovitis should be considered when swelling and decreased range of motion occur in the hands or digits of an immunocompromised host, especially if pain is not a prominent symptom.

Topics: Amphotericin B; Candidiasis; Child; Fluorouracil; Hand; Humans; Hypergammaglobulinemia; Male; Tendons; Tenosynovitis

Topics: Africa; Amphotericin B; Animals; Antimony; Asia, Western; Biopsy, Needle; Bone Marrow Examination; Brazil; Diagnosis, Differential; Disease Reservoirs; Humans; Hypergammaglobulinemia; Immunoglobulin G; India; Leishmaniasis, Visceral; Skin Tests; Splenomegaly; Stilbamidines; Zoonoses

Topics: Agammaglobulinemia; Amphotericin B; Antifungal Agents; Candidiasis; Dermabrasion; Granuloma; Humans; Hypergammaglobulinemia; Plastics; Surgery, Plastic