amphotericin-b and Hip-Fractures

Oral norfloxacin prevented Gram-negative bacilluria in female patients with hip fractures, who needed medium-term transurethral catheterization. This was shown in a placebo-controlled double-blind study of 34 patients. Seventeen of these received a suspension containing 200 mg norfloxacin and 500 mg amphotericin B, twice daily. In the placebo group, six cases of Gram-negative bacilluria had occurred by day 7, as compared with no cases during a median time of catheterization of 23 days in the group on medication. Bacteriuria, either by Gram-positive cocci or by Gram-negative bacilli, was observed in 50% of patients on placebo by day 7; in the treatment group this was the case by day 17 (P less than 0.001). Subsequent bacteriuria with Gram-positive cocci was eliminated by nitrofurantoin (50 mg qid) within four days. Norfloxacin is very suitable for the prevention of Gram-negative bacilluria, because it decontaminates Gram-negative bacilli from the bowel, reaches high concentrations in urine and rarely produces resistant variants.

Topics: Aged; Aged, 80 and over; Amphotericin B; Bacteriuria; Candida albicans; Digestive System; Feces; Female; Gram-Negative Bacteria; Hip Fractures; Humans; Norfloxacin; Urinary Catheterization

A challenging case of a nonunion of the proximal femur complicated by infection attributed to microbial and fungal pathogens requiring a combination of novel surgical techniques to achieve eradication of infection, preservation of the native hip joint, and restoration of function.

Topics: Adult; Amoxicillin; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Bone Cements; Candidiasis; Fluconazole; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Ununited; Hip Fractures; Humans; Male; Recovery of Function; Staphylococcal Infections; Treatment Outcome; Vancomycin; Wound Infection