amphotericin-b and Hepatitis-A

To report a case of foveal and macular intraretinal hemorrhages in an immunocompetent male patient with visceral leishmaniasis.. An immunocompetent, 42 year-old male, presented with progressive visual loss and metamorphopsia in his right eye. The fundus examination showed a foveal round yellow lesion and intraretinal hemorrhages in the macula. The patient was hospitalized with fever, anorexia, weight loss, hepatosplenomegaly, and progressive anemia. Laboratory studies were conducted and a positive test for leishmaniasis and hepatitis A was reported. Treatment was begun with amphotericin B 50mg/day up to a total dose of 1400mg.. Bilateral retinal hemorrhages in an endemic country could suggest the diagnosis of visceral leishmaniasis.

Topics: Adult; Amphotericin B; Animals; Antiprotozoal Agents; Blood Transfusion; Combined Modality Therapy; Dog Diseases; Dogs; Endemic Diseases; Fovea Centralis; Hepatitis A; Humans; Immunocompetence; Leishmaniasis, Visceral; Male; Paraguay; Retinal Hemorrhage; Scotoma; Zoonoses

The main non-HIV presentations at the 1995 Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) are reviewed. Issues addressed vancomycin resistance, the use of antibiotics in overcoming drug resistance, two new classes of antibiotics that are active against resistant gram-positive bacteria, hepatitis A screening for low-risk prospective travelers to developing countries, a new antiviral agent (valaciclovir) for use against genital herpes, amphotericin B lipid therapy for invasive candidiasis, and cryptosporidium as a major cause of severe diarrhea.

Topics: Acyclovir; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Candidiasis; Cryptosporidium; Diarrhea; Drug Carriers; Drug Resistance, Microbial; Gram-Positive Bacteria; Hepatitis A; Herpes Genitalis; Valacyclovir; Valine; Vancomycin