amphotericin-b and Granuloma--Respiratory-Tract

This is the first report of bronchocentric granulomatosis due to Aspergillus terreus in a healthy and non-asthmatic 74-year-old Japanese woman. Following identification of the fungus, oral itraconazole therapy was begun after intrabronchial infusion of amphotericin B. No recurrence has occurred after treatment for 24 months. We should consider the possibility of bronchocentric granulomatosis including Aspergillus terreus, when an intrabronchial lesion is found even in a healthy and non-asthmatic person. Oral itraconazole after intrabronchial infusion of amphotericin B seems to be effective in such cases.

Topics: Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Bronchial Diseases; Female; Granuloma, Respiratory Tract; Humans; Immunocompetence; Tomography, X-Ray Computed