amphotericin-b and Genital-Diseases--Female

Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Mycoses; Urologic Diseases

Genitourinary fungal infections have become increasingly common in clinical practice. We review the literature on such infections, emphasizing recognition of fungal disease, predisposing factors, pathogenesis, and approaches to therapy.

Topics: Amphotericin B; Aspergillosis; Blastomycosis; Candidiasis; Coccidioidomycosis; Cryptococcosis; Female; Genital Diseases, Female; Genital Diseases, Male; Histoplasmosis; Humans; Infant, Newborn; Male; Mycoses; Urinary Tract Infections

Although fungal urinary tract infections occur less frequently than bacterial urinary tract infections their incidence has increased during the last several decades and their clinical importance to the urologist should not be underestimated. Herein the pertinent literature on fungal urinary tract infections is reviewed, with emphasis on the predisposing factors, pathogenesis, host defense mechanisms and the clinical spectrum of the disease. An approach to the evaluation of positive cultures and therapy is presented.

Topics: Amphotericin B; Animals; Candida; Candidiasis; Female; Flucytosine; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Mice; Mycoses; Urinary Tract Infections

Deep-seated Candida infections are strongly associated with mortality and morbidity of patients, and need early diagnosis. The frequency of deep-seated fungal infection has recently been growing. We encountered a tuboovarian abscess caused by Candida glabrata after chemotherapy with an anticancer drug, methotrexate, in a febrile neutropenic patient. The susceptibilities to fluconazole and amphotericin B were 16 and 0.5 micro g/ml, respectively. Although combination therapy of fluconazole and amphotericin B was effective, left salpingectomy was laparoscopically performed because the left adnexal tumor continued to exist asymptomatically after 1 month.

Topics: Abscess; Adult; Amphotericin B; Antifungal Agents; Antimetabolites, Antineoplastic; Candida glabrata; Candidiasis; Diagnosis, Differential; Fallopian Tubes; Female; Fever; Fluconazole; Genital Diseases, Female; Granulocyte Colony-Stimulating Factor; Humans; Hydatidiform Mole; Magnetic Resonance Imaging; Methotrexate; Neutropenia; Pregnancy

Topics: Adolescent; Adult; Amphotericin B; Bacterial Infections; Candidiasis, Vulvovaginal; Drug Combinations; Female; Genital Diseases, Female; Humans; Middle Aged; Pelvic Inflammatory Disease; Suppositories; Tetracycline; Vaginitis

Candidiasis often is the final insult to the critically ill patient. Flucytosine, an orally administered antifungal agent, was used in the treatment of 225 patients with genitourinary candidiasis. Criteria for treatment included clinical manifestations, high urine colony counts of Candida, serologic findings and in vitro sensitivity of Candida to flucytosine. Infection was eradicated in 212 patients (94 per cent), as determined by clinical and laboratory criteria. The only significant adverse drug effect was reversible agranulocytosis, which ccurred in 2 patients. Thirteen patients (6 per cent) required supplemental therapy with systemic or bladder irrigations of amphotericin B.

Topics: Agranulocytosis; Amphotericin B; Candidiasis; Cytosine; Female; Flucytosine; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Urinary Tract Infections

Topics: Amphotericin B; Chlamydia Infections; Chloramphenicol; Condylomata Acuminata; Female; gamma-Globulins; Genital Diseases, Female; Genital Diseases, Male; Herpes Zoster; Humans; Immunoglobulins; Lymphogranuloma Venereum; Male; Molluscum Contagiosum; Mumps; Mycoplasma Infections; Orchitis; Podophyllin; Tetracycline; Vaccination; Vaccinia; Virus Diseases

Three cases of coccidioidomycosis of the female genital tract are reviewed. The diagnosis was made by laparotomy in 2 patients who presented with tender adnexal masses, and by endometrical curettage in a third patient with disseminated coccidioidomycosis. Hysterectomies were performed in all 3 patients; 1 had a bilateral salpingo-oophorectomy and the others a bilteral salpingectomy and unilateral oophorectomy. Two patients received chemotherapy with amphotericin B. One patient died 4 years after her operation from disseminated and meningeal coccidioidomycosis. In a female patient who has resided in an endemic region and who presents with pelvic pain of obscure origin, unexplained infertility, a menstrual disorder, or a chronic, refractory pelvic inflammatory disease, genital coccidioidomycosis should be considered in the differential diagnosis.

Topics: Adolescent; Adult; Amphotericin B; Coccidioidomycosis; Curettage; Diabetes Complications; Fallopian Tubes; Female; Genital Diseases, Female; Genitalia, Female; Humans; Hysterectomy; Laparotomy; Ovary

Topics: Abortion, Septic; Adult; Amphotericin B; Anti-Bacterial Agents; Candida; Candidiasis; Carcinoma, Squamous Cell; Female; Genital Diseases, Female; Humans; Immunosuppressive Agents; Middle Aged; Nystatin; Postoperative Complications; Pregnancy; Uterine Cervical Neoplasms

Topics: Aminosalicylic Acids; Amphotericin B; Blastomycosis; Coitus; Endometritis; Epididymis; Fallopian Tubes; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Isoniazid; Lung; Male; Middle Aged; Peritoneal Diseases; Prostatic Diseases; Radiography; Sexually Transmitted Diseases; Testicular Diseases; Urogenital System; Urologic Diseases; Uterine Diseases

Topics: Amphotericin B; Bacteria; Female; Fungi; Genital Diseases, Female; Humans; Pregnancy; Puerperal Infection; Tetracycline